![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
|
PDF (Original article incl. supplement)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
3MB | |
![[img]](http://edoc.mdc-berlin.de/style/images/fileicons/video.png) |
Video (MPEG) (Video1)
1MB |
| Item Type: | Article |
|---|---|
| Title: | Neuron-astrocyte interactions in the medial nucleus of the trapezoid body |
| Creators Name: | Reyes-Haro, D. and Mueller, J. and Boresch, M. and Pivneva, T. and Benedetti, B. and Scheller, A. and Nolte, C. and Kettenmann, H. |
| Abstract: | The calyx of Held (CoH) synapse serves as a model system to analyze basic mechanisms of synaptic transmission. Astrocyte processes are part of the synaptic structure and contact both pre- and postsynaptic membranes. In the medial nucleus of the trapezoid body (MNTB), midline stimulation evoked a current response that was not mediated by glutamate receptors or glutamate uptake, despite the fact that astrocytes express functional receptors and transporters. However, astrocytes showed spontaneous Ca(2+) responses and neuronal slow inward currents (nSICs) were recorded in the postsynaptic principal neurons (PPNs) of the MNTB. These currents were correlated with astrocytic Ca(2+) activity because dialysis of astrocytes with BAPTA abolished nSICs. Moreover, the frequency of these currents was increased when Ca(2+) responses in astrocytes were elicited. NMDA antagonists selectively blocked nSICs while D-serine degradation significantly reduced NMDA-mediated currents. In contrast to previous studies in the hippocampus, these NMDA-mediated currents were rarely synchronized. |
| Keywords: | Amino Acid Transport System X-AG, Anthozoa, Astrocytes, Brain Stem, Calcium, Cell Communication, Chelating Agents, Electric Stimulation, Excitatory Amino Acid Antagonists, Glutamic Acid, Green Fluorescent Proteins, Membrane Potentials, N-Methylaspartate, Nerve Tissue Proteins, Neurons, Glutamate Receptors, N-Methyl-D-Aspartate Receptors, Recombinant Fusion Proteins, Serine, Synapses, Synaptic Transmission, Time Factors, Animals, Mice |
| Source: | Journal of General Physiology |
| ISSN: | 0022-1295 |
| Publisher: | Rockefeller University Press |
| Volume: | 135 |
| Number: | 6 |
| Page Range: | 583-594 |
| Date: | June 2010 |
| Official Publication: | https://doi.org/10.1085/jgp.200910354 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
Download Statistics
Download Statistics
