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Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats

Item Type:Article
Title:Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats
Creators Name:Hilbert, P. and Lindpaintner, K. and Beckmann, J.S. and Serikawa, T. and Soubrier, F. and Dubay, C.J. and Cartwright, P. and De Gouyon, B. and Julier, C. and Takahashi, S. and Vincent, M. and Ganten, D. and Georges, M. and Lathrop, G.M.
Abstract:The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneously hypertensive rat and the normotensive control strain Wistar-Kyoto have led to the localization of two genes, BP/SP-1 and BP/SP-2, that contribute significantly to blood pressure variation in the F2 population. BP/SP-1 and BP/SP-2 were assigned to rat chromosomes 10 and X, respectively. Comparison of the human and rat genetic maps indicates that BP/SP-1 could reside on human chromosome 17q in a region that also contains the angiotensin I-converting enzyme gene (ACE). This encodes a key enzyme of the renin-angiotensin system, and is therefore a candidate gene in primary hypertension. A rat microsatellite marker of ACE was mapped to rat chromosome 10 within the region containing BP/SP-1.
Keywords:Base Sequence, Cell Surface Receptors, Chromosome Mapping, Genetic Linkage, Hypertension, Molecular Sequence Data, Nerve Growth Factor Receptors, Peptidyl-Dipeptidase A, Polymerase Chain Reaction, Somatotropin Receptors, X Chromosome, Animals, Rats
Source:Nature
ISSN:0028-0836
Publisher:Nature Publishing Group (U.K.)
Volume:353
Number:6344
Page Range:521-529
Date:10 October 1991
Official Publication:https://doi.org/10.1038/353521a0
PubMed:View item in PubMed

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