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| Item Type: | Article |
|---|---|
| Title: | Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats |
| Creators Name: | Hilbert, P., Lindpaintner, K., Beckmann, J.S., Serikawa, T., Soubrier, F., Dubay, C.J., Cartwright, P., De Gouyon, B., Julier, C., Takahashi, S., Vincent, M., Ganten, D., Georges, M. and Lathrop, G.M. |
| Abstract: | The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneously hypertensive rat and the normotensive control strain Wistar-Kyoto have led to the localization of two genes, BP/SP-1 and BP/SP-2, that contribute significantly to blood pressure variation in the F2 population. BP/SP-1 and BP/SP-2 were assigned to rat chromosomes 10 and X, respectively. Comparison of the human and rat genetic maps indicates that BP/SP-1 could reside on human chromosome 17q in a region that also contains the angiotensin I-converting enzyme gene (ACE). This encodes a key enzyme of the renin-angiotensin system, and is therefore a candidate gene in primary hypertension. A rat microsatellite marker of ACE was mapped to rat chromosome 10 within the region containing BP/SP-1. |
| Keywords: | Base Sequence, Cell Surface Receptors, Chromosome Mapping, Genetic Linkage, Hypertension, Molecular Sequence Data, Nerve Growth Factor Receptors, Peptidyl-Dipeptidase A, Polymerase Chain Reaction, Somatotropin Receptors, X Chromosome, Animals, Rats |
| Source: | Nature |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Volume: | 353 |
| Number: | 6344 |
| Page Range: | 521-529 |
| Date: | 10 October 1991 |
| Official Publication: | https://doi.org/10.1038/353521a0 |
| PubMed: | View item in PubMed |
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