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| Item Type: | Article |
|---|---|
| Title: | Tumor rejection by local interferon gamma induction in established tumors is associated with blood vessel destruction and necrosis |
| Creators Name: | Briesemeister, D. and Sommermeyer, D. and Loddenkemper, C. and Loew, R. and Uckert, W. and Blankenstein, T. and Kammertoens, T. |
| Abstract: | It has been shown that injecting a suspension of IFN-gamma-secreting tumor cells results in their rejection. This effect has been attributed to IFN-gamma preventing tumor stroma formation but not to a direct effect on the cancer cells. However, it is not known, which influence IFN-gamma has on tumors with an established stroma. To address this question, the plasmacytoma cell line J558L was transduced with a vector allowing doxycycline-inducible IFN-gamma gene expression. After the injection of the tumor cells into mice, IFN-gamma was induced at different time points. Tumors did not grow when inducing IFN-gamma immediately after tumor cell inoculation, while approximately half of the tumors were rejected when IFN-gamma was induced in early established tumors within 2 weeks. Induction of IFN-gamma 2-3 weeks after tumor cell inoculation was less efficient (0-17% rejection). IFN-gamma induction in established tumors led to a reduction of CD146(+) endothelial cells and massive necrosis. Together, we show that vascularized tumors can be rejected by local IFN-gamma expression, but that rejection of established tumors was less efficient over time. This suggests that transplanted tumors became less susceptible to local IFN-gamma treatment the better they are established. |
| Keywords: | Interferon gamma, Tumor Microenvironment, Established Tumors, Animals, Mice |
| Source: | International Journal of Cancer |
| ISSN: | 0020-7136 |
| Publisher: | Wiley |
| Volume: | 128 |
| Number: | 2 |
| Page Range: | 371-378 |
| Date: | 15 January 2011 |
| Official Publication: | https://doi.org/10.1002/ijc.25350 |
| PubMed: | View item in PubMed |
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