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Electrogenic sodium-bicarbonate symport in cultured corneal endothelial cells

Item Type:Article
Title:Electrogenic sodium-bicarbonate symport in cultured corneal endothelial cells
Creators Name:Wiederholt, M. and Jentsch, T.J. and Keller, S.K.
Abstract:Intracellular potential measurements on confluent monolayers of cultured bovine corneal endothelial cells were used to define passive ion transport processes in these cells. Previous studies [11, 12] have provided the experimental basis for a cellular model, is which bicarbonate entry across the basolateral membrane in indirectly driven by a Na+/H+-exchanger, which is inhibitable by amiloride (1 mmol/l). Na+ and HCO3- leave the cell via an electrogenic bicarbonate sodium cotransport, which is inhibitable by the disulfonic stilbene derivates SITS or DIDS. This model is also compatible with transepithelial work from other groups. In this paper, we briefly review the evidence we have obtained for this model.
Keywords:Corneal Endothelium, Cell Culture, Intracellular Potential, Sodium-Bicarbonate Cotransport, pH Regulation, Stilbenes, Animals, Cattle
Source:Pfluegers Archiv European Journal of Physiology
ISSN:0031-6768
Publisher:Springer (Germany)
Volume:405
Number:Suppl 1
Page Range:S167-S171
Date:March 1985
Official Publication:https://doi.org/10.1007/BF00581801
PubMed:View item in PubMed

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