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Molecular physiology of anion channels

Item Type:Article
Title:Molecular physiology of anion channels
Creators Name:Jentsch, T.J.
Abstract:Anion channels have diverse functions, ranging from regulation of cell volume to transepithelial transport and control of excitability. Three well established structural classes of plasma membrane chloride channels now exist: the ligand-gated chloride channels, the cAMP-stimulated cystic fibrosis transmembrane conductance regulator channel, and the voltage-gated (or swelling-activated) members of the CLC chloride channel family. Genetic defects leading to inherited disease are known for each of these classes. A combination of mutagenesis and biophysical analysis has been used to correlate their structure with function. Recently, the role of several molecules has been questioned; rather than being chloride channels themselves, they may be activators of endogenous channels in the cells used for expression.
Keywords:Chloride Channels, Cystic Fibrosis, Electric Conductivity, Ion Channel Gating, Membrane Proteins
Source:Current Opinion in Cell Biology
ISSN:0955-0674
Publisher:Elsevier / Current Biology (U.K.)
Volume:6
Number:4
Page Range:600-606
Date:August 1994
Official Publication:https://doi.org/10.1016/0955-0674(94)90082-5
PubMed:View item in PubMed

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