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Chloride channels: a molecular perspective

Item Type:Article
Title:Chloride channels: a molecular perspective
Creators Name:Jentsch, T.J.
Abstract:Plasma membrane Cl- channels perform a variety of functions, including control of excitability in neurons and muscle, cell volume regulation and transepithelial transport. Structurally, three classes of Cl- channels have been identified: ligand-gated, postsynaptic Cl- channels (e.g. GABA and glycine receptors); the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels (which belong to the traffic ATPase superfamily); and the CLC family of Cl- channels. Recent developments of note include further characterization of the expanding CLC Cl- channel family, advances in understanding the regulation of the CFTR Cl- channel and its emergent role as a regulator of other channels, clarification of issues related to swelling-activated Cl- channels, and the discovery that several co-transporter molecules are now known to induce Cl- currents in Xenopus oocytes.
Keywords:Carrier Proteins, Chloride Channels, Cystic Fibrosis Transmembrane Conductance Regulator, Electric Conductivity, Oocytes, Osmosis, Animals
Source:Current Opinion in Neurobiology
Publisher:Current Biology
Page Range:303-310
Date:June 1996
Official Publication:https://doi.org/10.1016/S0959-4388(96)80112-7
PubMed:View item in PubMed

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