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Heteromultimeric CLC chloride channels with novel properties

Item Type:Article
Title:Heteromultimeric CLC chloride channels with novel properties
Creators Name:Lorenz, C. and Pusch, M. and Jentsch, T.J.
Abstract:The skeletal muscle chloride channel CLC-1 and the ubiquitous volume-activated chloride channel CLC-2 belong to a large gene family whose members often show overlapping expression patterns. CLC-1 and CLC-2 are coexpressed in skeletal and smooth muscle and in the heart. By coexpressing CLC-1 and CLC-2 in Xenopus oocytes, we now show the formation of novel CLC-1/CLC-2 heterooligomers that yield time-independent linear chloride currents with a chloride-->bromide-->iodide selectivity sequence. Formation of heterooligomeric CLC channels increases the number and possible functions of chloride channels.
Keywords:Anion Channel, Multimers, Myotonia, Cystic Fibrosis, Cell Volume Regulation, Animals, Xenopus Laevis
Source:Proceedings of the National Academy of Sciences of the United States of America
ISSN:0027-8424
Publisher:National Academy of Sciences (U.S.A.)
Volume:93
Number:23
Page Range:13362-13366
Date:12 November 1996
Official Publication:http://www.pnas.org/content/93/23/13362.abstract
PubMed:View item in PubMed

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