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KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents

Item Type:Article
Title:KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents
Creators Name:Schroeder, B.C. and Hechenberger, M. and Weinreich, F. and Kubisch, C. and Jentsch, T.J.
Abstract:KCNQ2 and KCNQ3, both of which are mutated in a type of human neonatal epilepsy, form heteromeric potassium channels that are expressed in broad regions of the brain. The associated current may be identical to the M-current, an important regulator of neuronal excitability. We now show that the RNA encoding the novel KCNQ5 channel is also expressed in brain and in sympathetic ganglia where it overlaps largely with KCNQ2 and KCNQ3. In addition, it is expressed in skeletal muscle. KCNQ5 yields currents that activate slowly with depolarization and can form heteromeric channels with KCNQ3. Currents expressed from KCNQ5 have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. A KCNQ5 splice variant found in skeletal muscle displays altered gating kinetics. This indicates a molecular diversity of channels yielding M-type currents and suggests a role for KCNQ5 in the regulation of neuronal excitability.
Keywords:Alternative Splicing, Amino Acid Sequence, Brain Chemistry, Electric Conductivity, Electrophysiology, In Situ Hybridization, KCNQ Potassium Channels, Membrane Potentials, Molecular Sequence Data, Nerve Tissue Proteins, Voltage-Gated Potassium Channels, Messenger RNA, Amino Acid Sequence Homology, Superior Cervical Ganglion, Tissue Distribution, Animals, Rats
Source:Journal of Biological Chemistry
ISSN:0021-9258
Publisher:American Society for Biochemistry and Molecular Biology (U.S.A.)
Volume:275
Number:31
Page Range:24089-24095
Date:4 August 2000
Official Publication:https://doi.org/10.1074/jbc.M003245200
PubMed:View item in PubMed

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