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Ion channel diseases

Item Type:Review
Title:Ion channel diseases
Creators Name:Huebner, C.A. and Jentsch, T.J.
Abstract:Ion channels serve many functions apart from electrical signal transduction: chemical signalling (Ca(2+) as a second messenger), transepithelial transport, regulation of cytoplasmic or vesicular ion concentration and pH, and regulation of cell volume. Therefore, ion channel dysfunction can cause diseases in many tissues. The list of human diseases known to be associated with defects in ion channels has grown considerably during the past years. This review gives a short overview of known channelopathies, and focuses in particular on recent findings and on channelopathies that have significantly advanced our physiological insight.
Keywords:Cardiac Arrhythmias, Bone Diseases, Endocrine System Diseases, Ion Channels, Kidney Diseases, Skeletal Muscle, Nervous System Diseases, Animals
Source:Human Molecular Genetics
ISSN:0964-6906
Publisher:Oxford University Press (U.K.)
Volume:11
Number:20
Page Range:2435-2445
Date:1 October 2002
Official Publication:http://hmg.oxfordjournals.org/cgi/content/abstract/11/20/2435
PubMed:View item in PubMed

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