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A role for chloride transport in lysosomal protein degradation

Item Type:Editorial
Title:A role for chloride transport in lysosomal protein degradation
Creators Name:Wartosch, L. and Stauber, T.
Abstract:Loss of the lysosomal chloride transport protein ClC-7 leads to complex phenotypes in mice and man, including osteopetrosis, accumulation of lysosomal storage material, and neurodegeneration. Using novel tissue-specific ClC-7 knockout mice, we have shown that upon loss of ClC-7, lysosomal degradation of endocytosed protein is slowed down and accumulation of autophagosomes occurs.
Keywords:Biological Transport, Chloride Channels, Chlorides, Lysosomes, Post-Translational Protein Processing, Animals, Mice
Source:Autophagy
ISSN:1554-8627
Publisher:Landes Bioscience (U.S.A.)
Volume:6
Number:1
Page Range:158-159
Date:January 2010
Official Publication:https://doi.org/10.4161/auto.6.1.10590
PubMed:View item in PubMed

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