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Guiding embryonic stem cells towards differentiation: lessons from molecular embryology

Item Type:Review
Title:Guiding embryonic stem cells towards differentiation: lessons from molecular embryology
Creators Name:Spagnoli, F.M. and Hemmati-Brivanlou, A.
Abstract:Embryonic stem cells are uniquely endowed with the capacity of self-renewal and the potential to give rise to all possible cell types, including germ cells. These qualities have made mouse embryonic stem cells a valuable resource for genetic manipulation of the mouse genome. In addition, they present a powerful system for the in vitro dissection of mammalian embryonic development. The recent isolation of human embryonic stem cells has raised a lot of interest for the potential of transposing our knowledge of lineage-specific differentiation of embryonic stem cells to cell-based therapy of human disease. Recent reports have provided insights into the specific differentiation of embryonic stem cells to different cell types of the embryo. However, progress in this direction seems to depend on the knowledge of the mechanisms controlling lineage decisions during embryogenesis.
Keywords:Cell Differentiation, Cell Lineage, Developmental Biology, Mammalian Embryo, Gene Expression Regulation, Developmental, Stem Cells, Animals
Source:Current Opinion in Genetics & Development
ISSN:0959-437X
Publisher:Current Biology (U.S.A.)
Volume:16
Number:5
Page Range:469-475
Date:October 2006
Official Publication:https://doi.org/10.1016/j.gde.2006.08.004
PubMed:View item in PubMed

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