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From endoderm to pancreas: a multistep journey

Item Type:Review
Title:From endoderm to pancreas: a multistep journey
Creators Name:Spagnoli, F.M.
Abstract:The formation of the vertebrate pancreas is a complex process that typifies the basic steps of embryonic development. It involves the establishment of competence, specification, signaling from neighboring tissues, morphogenesis, and the elaboration of tissue-specific genetic networks. A full analysis of this multistep process will help us to understand classic principles of embryonic development. Furthermore, this will provide the blueprint for experimental programming of pancreas formation from embryonic stem cells in the context of diabetes cell-therapy. Although in the past decade many studies have contributed to a solid foundation for understanding pancreatogenesis, important gaps persist in our knowledge of early pancreas formation. This review will summarize the current understanding of the early mechanisms coming into play to pattern the "pre-pancreatic" region within the endoderm and, gradually, specify the pancreatic tissue.
Keywords:Pancreas, Embryonic Development, Endoderm, Diabetes, Stem Cells, Animals
Source:Cellular and Molecular Life Sciences
Page Range:2378-2390
Date:September 2007
Official Publication:https://doi.org/10.1007/s00018-007-7184-x
PubMed:View item in PubMed

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