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Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart

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Item Type:Article
Title:Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart
Creators Name:Buttgereit, J. and Qadri, F. and Monti, J. and Langenickel, T.H. and Dietz, R. and Braunewell, K.H. and Bader, M.
Abstract:Accumulating evidence indicates that Visinin-like protein-1 (VILIP-1), a member of the family of neuronal calcium sensor proteins (NCS), modulates a variety of processes in extra-neuronal tissues. In this study, we describe VILIP-1 expression in the human heart, rat cardiomyocytes, and H9c2 cells, and demonstrate that VILIP-1 regulates the cell surface localization of natriuretic peptide receptor B (NPR-B). In preparations from failing hearts, we observed VILIP-1 downregulation and reduced NPR-B signalling. In conclusion, VILIP-1 deficiency may be responsible for the reduced efficiency of the natriuretic peptide system in cardiac hypertrophy and heart failure and may therefore serve as pharmacological target.
Keywords:Visinin-Like Protein-1, VILIP-1, Natriuretic Peptide Receptor B, NPR-B, Cardiac Hypertrophy, Heart Failure, Animals, Rats
Source:Regulatory Peptides
ISSN:0167-0115
Publisher:Elsevier (The Netherlands)
Volume:161
Number:1-3
Page Range:51-57
Date:9 April 2010
Official Publication:https://doi.org/10.1016/j.regpep.2009.12.019
PubMed:View item in PubMed

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