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| Item Type: | Article |
|---|---|
| Title: | Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart |
| Creators Name: | Buttgereit, J. and Qadri, F. and Monti, J. and Langenickel, T.H. and Dietz, R. and Braunewell, K.H. and Bader, M. |
| Abstract: | Accumulating evidence indicates that Visinin-like protein-1 (VILIP-1), a member of the family of neuronal calcium sensor proteins (NCS), modulates a variety of processes in extra-neuronal tissues. In this study, we describe VILIP-1 expression in the human heart, rat cardiomyocytes, and H9c2 cells, and demonstrate that VILIP-1 regulates the cell surface localization of natriuretic peptide receptor B (NPR-B). In preparations from failing hearts, we observed VILIP-1 downregulation and reduced NPR-B signalling. In conclusion, VILIP-1 deficiency may be responsible for the reduced efficiency of the natriuretic peptide system in cardiac hypertrophy and heart failure and may therefore serve as pharmacological target. |
| Keywords: | Visinin-Like Protein-1, VILIP-1, Natriuretic Peptide Receptor B, NPR-B, Cardiac Hypertrophy, Heart Failure, Animals, Rats |
| Source: | Regulatory Peptides |
| ISSN: | 0167-0115 |
| Publisher: | Elsevier |
| Volume: | 161 |
| Number: | 1-3 |
| Page Range: | 51-57 |
| Date: | 9 April 2010 |
| Official Publication: | https://doi.org/10.1016/j.regpep.2009.12.019 |
| PubMed: | View item in PubMed |
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