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Computer-assisted identification of small-molecule Bcl-2 modulators

Item Type:Article
Title:Computer-assisted identification of small-molecule Bcl-2 modulators
Creators Name:Fuellbeck, M. and Gebhardt, N. and Hossbach, J. and Daniel, P.T. and Preissner, R.
Abstract:Apoptosis, the programmed cell death, is a highly regulated process, necessary for normal development and homeostasis of the functions of organisms. The Bcl-2 inhibitors BH3I-1 and BH3I-2 were used as lead compounds to find possible Bcl-2 or Bcl-X(L) inhibitors by using computer-assisted screening with our in-house database, containing more than four million commercially available molecules. Identified compounds were further investigated regarding their possible application as a drug.
Keywords:Bcl-2, Apoptosis, Inhibitors, Computer-Assisted Screening
Source:Computational Biology and Chemistry
ISSN:1476-9271
Publisher:Elsevier (U.K.)
Volume:33
Number:6
Page Range:451-456
Date:December 2009
Official Publication:https://doi.org/10.1016/j.compbiolchem.2009.10.001
PubMed:View item in PubMed

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