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CCR7 regulates lymphocyte egress and recirculation through body cavities

Item Type:Article
Title:CCR7 regulates lymphocyte egress and recirculation through body cavities
Creators Name:Hoepken, U.E. and Winter, S. and Achtman, A.H. and Krueger, K. and Lipp, M.
Abstract:T and B lymphocytes recirculate among blood, lymph, and extralymphoid tissues to ensure immune surveillance and the establishment of self-tolerance. The underlying mechanisms regulating homeostatic lymphocyte recirculation through body cavities are not fully understood. Here, we demonstrate that the homeostatic chemokine receptor CCR7 regulates homeostatic recirculation of lymphocytes through body cavities. CCR7 deficiency results in massive accumulation of CD4(+) and CD8(+) T cells and B-2 B cells in the peritoneal and pleural cavities. The increase in B-2 B and T lymphocytes is not associated with an altered maturation and/or activation status of these cells. Mechanistically, an increase in peritoneal lymphocyte numbers is caused by impaired egress of CCR7-deficient lymphocytes from body cavities. These results establish that CCR7 plays a crucial role in lymphocyte exit from the PerC.
Keywords:Chemokine Receptor, Peritoneal Cavity, Homeostatic, Recirculation, Exit Signal, Animals, Mice
Source:Journal of Leukocyte Biology
ISSN:0741-5400
Publisher:Oxford University Press (U.K.)
Volume:87
Number:4
Page Range:671-682
Date:April 2010
Official Publication:https://doi.org/10.1189/jlb.0709505
PubMed:View item in PubMed

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