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Dysregulated Epstein-Barr virus infection in patients with CIDP

Item Type:Article
Title:Dysregulated Epstein-Barr virus infection in patients with CIDP
Creators Name:Luenemann, J.D. and Tackenberg, B. and Stein, A. and Wandinger, K.P. and Oertel, W.H. and Wagner, H.J. and Muenz, C. and Meisel, H. and Sommer, N. and Zipp, F.
Abstract:Ubiquitous viruses have frequently been proposed as a cause or trigger of chronic immune-mediated diseases. Infections are reported to be temporally associated with clinical exacerbations in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We examined immunological parameters of herpesvirus infections in untreated patients with CIDP compared to demographically matched controls. Patients with CIDP were uniformly seropositive for EBV-specific IgG and the disease was associated with a moderately enhanced IgG reactivity to EBV-encoded antigens expressed during both B cell transformation and productive viral replication. Moreover, cellular EBV copy numbers were 3-fold increased in patients with CIDP. In contrast, humoral immune responses to other herpesviruses (HCMV, HSV) as well as virus-specific IgM responses were unchanged in CIDP. These data indicate that host-pathogen interactions during chronic EBV infection are dysregulated in treatment-naïve patients with CIDP.
Keywords:CIDP, Autoimmunity, Infection, EBV, Herpesvirus
Source:Journal of Neuroimmunology
ISSN:0165-5728
Publisher:Elsevier (The Netherlands)
Volume:218
Number:1-2
Page Range:107-111
Date:25 January 2010
Official Publication:https://doi.org/10.1016/j.jneuroim.2009.11.003
PubMed:View item in PubMed

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