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AQUA: Automated quality improvement for multiple sequence alignments

Item Type:Article
Title:AQUA: Automated quality improvement for multiple sequence alignments
Creators Name:Muller, J. and Creevey, C.J. and Thompson, J.D. and Arendt, D. and Bork, P.
Abstract:Multiple Sequence Alignment (MSA) is a central tool in most modern biology studies. However, despite generations of valuable tools, human experts are still able to improve automatically generated MSAs. In an effort to automatically identify the most reliable MSA for a given protein family, we propose a very simple protocol, named AQUA for "Automated quality improvement for multiple sequence alignments". Our current implementation relies on 2 alignment programs (MUSCLE and MAFFT), one refinement program (RASCAL) and one assessment program (NORMD) but other programs could be incorporated at any of the 3 steps. AVAILABILITY: AQUA is implemented in Tcl/Tk and runs in command line on all platforms. The source code is available under the GNU GPL license. Source code, README and Supplementary data are available at http://www.bork.embl.de/Docu/AQUA. CONTACT: muller@embl.de, bork@embl.de.
Keywords:Computational Biology, Protein Databases, Proteins, Sequence Alignment, Protein Sequence Analysis, Software
Source:Bioinformatics
ISSN:1367-4803
Publisher:Oxford University Press (U.K.)
Volume:26
Number:2
Page Range:263-265
Date:15 January 2010
Official Publication:https://doi.org/10.1093/bioinformatics/btp651
PubMed:View item in PubMed

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