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Ageing-related chromatin defects through loss of the NURD complex

Official URL:https://doi.org/10.1038/ncb1971
PubMed:View item in PubMed
Creators Name:Pegoraro, G. and Kubben, N. and Wickert, U. and Goehler, H. and Hoffmann, K. and Misteli, T.
Journal Title:Nature Cell Biology
Journal Abbreviation:Nat Cell Biol
Volume:11
Number:10
Page Range:1261-1267
Date:October 2009
Keywords:Hutchinson-Gilford-Progeria, Protein Interaction Network, Human Cells, S-Phase, Methylation, Transcription, Stability, Enhancer, Disease, Genome
Abstract:Physiological and premature ageing are characterized by multiple defects in chromatin structure and accumulation of persistent DNA damage. Here we identify the NURD chromatin remodelling complex as a key modulator of these ageing-associated chromatin defects. We demonstrate loss of several NURD components during premature and normal ageing and we find an ageing-associated reduction in HDAC1 activity. Silencing of individual NURD subunits recapitulated chromatin defects associated with ageing and we provide evidence that structural chromatin defects precede DNA damage accumulation. These results outline a molecular mechanism for chromatin defects during ageing.
ISSN:1465-7392
Publisher:Nature Publishing Group (U.K.)
Item Type:Article

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