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Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion

Item Type:Article
Title:Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion
Creators Name:Zick, M. and Duvezin-Caubet, S. and Schaefer, A. and Vogel, F. and Neupert, W. and Reichert, A.S.
Abstract:The mitochondrial dynamin-like GTPase Mgm1 exists as a long (l-Mgm1) and a short isoform (s-Mgm1). They both are essential for mitochondrial fusion. Here we show that the isoforms interact in a homotypic and heterotypic manner. Their submitochondrial distribution between inner boundary membrane and cristae was markedly different. Overexpression of l-Mgm1 exerts a dominant negative effect on mitochondrial fusion. A functional GTPase domain is required only in s-Mgm1 but not in l-Mgm1. We propose that l-Mgm1 acts primarily as an anchor in the inner membrane that in concert with the GTPase activity of s-Mgm1 mediates the fusion of inner membranes.
Keywords:Mitochondria, Membrane Fusion, Mitochondrial DNA, Mgm1, Genetic Analysis, Dynamin-Like GTPase
Source:FEBS Letters
ISSN:0014-5793
Publisher:Elsevier (The Netherlands)
Volume:583
Number:13
Page Range:2237-2243
Date:7 July 2009
Official Publication:https://doi.org/10.1016/j.febslet.2009.05.053
PubMed:View item in PubMed

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