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Quantitative proteomics: a tool to assess cell differentiation

Official URL:https://doi.org/10.1016/j.ceb.2009.09.003
PubMed:View item in PubMed
Creators Name:Vermeulen, M. and Selbach, M.
Journal Title:Current Opinion in Cell Biology
Journal Abbreviation:Curr Opin Cell Biol
Volume:21
Number:6
Page Range:761-766
Date:December 2009
Keywords:Cell Differentiation, Chromatin, Histones, Mass Spectrometry, Proteome, Proteomics, Post-Transcriptional RNA Processing, Animals
Abstract:During cell differentiation, gene expression is regulated at multiple levels which is only partially captured by transcription profiling. In recent years it became increasingly clear that post-translational modifications of core histones and post-transcriptional regulation by RNA-binding proteins and microRNAs play an important role during differentiation. Recent advances in mass spectrometry-based quantitative proteomics now allow for genome-wide analyses at the protein level. This technology provides a powerful toolbox that can be used to study different levels of gene regulation and reveal their importance during development of multi-cellular organisms. We highlight recent studies and indicate how quantitative proteomics can be employed to investigate cell differentiation in the future.
ISSN:0955-0674
Publisher:Elsevier (The Netherlands)
Item Type:Article

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