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The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling

Item Type:Article
Title:The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling
Creators Name:Wijk, N.V. and Witte, F. and Feike, A.C. and Schambony, A. and Birchmeier, W. and Mundlos, S. and Stricker, S.
Abstract:Wtip is a LIM domain protein of the Ajuba/Zyxin family involved in kidney and neural crest development; Ror2 is a receptor tyrosine kinase involved in the development of skeleton, heart, lung, genitalia and kidneys. Here we describe Wtip as an intracellular interaction partner of Ror2. Full-length Ror2 recruits Wtip to the cell membrane, a mutant involved in human disease fails to do so. Both genes and proteins show overlapping expression in the mouse embryo. We show that Wtip is able to inhibit canonical Wnt signalling in mammalian cells and in Xenopus embryos linking Wtip to a crucial developmental pathway.
Keywords:Wtip, Ror2, Brachydactyly, Wnt, Animals, Mice
Source:Biochemical and Biophysical Research Communications
ISSN:0006-291X
Publisher:Academic Press (U.S.A.)
Volume:390
Number:2
Page Range:211-216
Date:11 December 2009
Official Publication:https://doi.org/10.1016/j.bbrc.2009.09.086
PubMed:View item in PubMed

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