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Genetic influences on the pharmacokinetics of orally and intravenously administered digoxin as exhibited by monozygotic twins

Item Type:Article
Title:Genetic influences on the pharmacokinetics of orally and intravenously administered digoxin as exhibited by monozygotic twins
Creators Name:Birkenfeld, A.L. and Jordan, J. and Hofmann, U. and Busjahn, A. and Franke, G. and Krueger, N. and Igel, S. and Muerdter, T. and Drescher, S. and Shi, S. and Engeli, S. and Schwab, M. and Eichelbaum, M. and Luft, F.C. and Fromm, M.F.
Abstract:The expression and function of the drug transporter P-glycoprotein are highly variable. Environmental and genetic factors contribute to this variation. We studied the disposition of digoxin, a frequently used probe drug for P-glycoprotein function in humans, in monozygotic (MZ) twins and found that digoxin pharmacokinetics after oral and intravenous administration are highly correlated within MZ twins, supporting the hypothesis of a robust contribution from genetic variance. Our study suggests that studies involving twins could be more widely applied to elucidate pharmacogenetics.
Keywords:Oral Administration, Deuterium, Digoxin, Genetic Variation, Genotype, Intravenous Infusions, P-Glycoprotein, Phenotype, Pilot Projects, Registries, Monozygotic Twins, Human ABCB1 Protein
Source:Clinical Pharmacology and Therapeutics
ISSN:0009-9236
Publisher:Nature Publishing Group (U.S.A.)
Volume:86
Number:6
Page Range:605-608
Date:December 2009
Official Publication:https://doi.org/10.1038/clpt.2009.170
PubMed:View item in PubMed

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