Genetic influences on the pharmacokinetics of orally and intravenously administered digoxin as exhibited by monozygotic twins

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Item Type:	Article
Title:	Genetic influences on the pharmacokinetics of orally and intravenously administered digoxin as exhibited by monozygotic twins
Creators Name:	Birkenfeld, A.L., Jordan, J., Hofmann, U., Busjahn, A., Franke, G., Krueger, N., Igel, S., Muerdter, T., Drescher, S., Shi, S., Engeli, S., Schwab, M., Eichelbaum, M., Luft, F.C. and Fromm, M.F.
Abstract:	The expression and function of the drug transporter P-glycoprotein are highly variable. Environmental and genetic factors contribute to this variation. We studied the disposition of digoxin, a frequently used probe drug for P-glycoprotein function in humans, in monozygotic (MZ) twins and found that digoxin pharmacokinetics after oral and intravenous administration are highly correlated within MZ twins, supporting the hypothesis of a robust contribution from genetic variance. Our study suggests that studies involving twins could be more widely applied to elucidate pharmacogenetics.
Keywords:	Oral Administration, Deuterium, Digoxin, Genetic Variation, Genotype, Intravenous Infusions, P-Glycoprotein, Phenotype, Pilot Projects, Registries, Monozygotic Twins, Human ABCB1 Protein
Source:	Clinical Pharmacology and Therapeutics
ISSN:	0009-9236
Publisher:	Nature Publishing Group
Volume:	86
Number:	6
Page Range:	605-608
Date:	December 2009
Official Publication:	https://doi.org/10.1038/clpt.2009.170
PubMed:	View item in PubMed

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