Late-fluorescence mammography assesses tumor capillary permeability and differentiates malignant from benign lesions

Item Type:	Article
Title:	Late-fluorescence mammography assesses tumor capillary permeability and differentiates malignant from benign lesions
Creators Name:	Hagen, A. and Grosenick, D. and Macdonald, R. and Rinneberg, H. and Burock, S. and Warnick, P. and Poellinger, A. and Schlag, P.M.
Abstract:	Using scanning time-domain instrumentation we recorded fluorescence projection mammograms on few breast cancer patients prior, during and after infusion of indocyanine green (ICG), while monitoring arterial ICG concentration by transcutaneous pulse densitometry. Late-fluorescence mammograms recorded after ICG had been largely cleared from the blood by the liver, showed invasive carcinomas at high contrast over a rather homogeneous background, whereas benign lesions did not produce (focused) fluorescence contrast. During infusion, tissue concentration contrast and hence fluorescence contrast is determined by intravascular contributions, whereas late-fluorescence mammograms are dominated by contributions from protein-bound ICG extravasated into the interstitium, reflecting relative microvascular permeabilities of carcinomas and normal breast tissue. We simulated intravascular and extravascular contributions to ICG tissue concentration contrast within a two-compartment unidirectional pharmacokinetic model.
Keywords:	Breast Neoplasms, Capillary Permeability, Computer Simulation, Differential Diagnosis, Fluorescence, Indocyanine Green, Mammography, Time Factors
Source:	Optics Express
ISSN:	1094-4087
Publisher:	Optical Society of America
Volume:	17
Number:	19
Page Range:	17016-17033
Date:	14 September 2009
Official Publication:	https://doi.org/10.1364/OE.17.017016
PubMed:	View item in PubMed

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