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Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis

Item Type:Article
Title:Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis
Creators Name:Roepke, T.K. and King, E.C. and Reyna-Neyra, A. and Paroder, M. and Purtell, K. and Koba, W. and Fine, E. and Lerner, D.J. and Carrasco, N. and Abbott, G.W.
Abstract:Thyroid dysfunction is a global health concern, causing defects including neurodevelopmental disorders, dwarfism and cardiac arrhythmia. Here, we show that the potassium channel subunits KCNQ1 and KCNE2 form a thyroid-stimulating hormone-stimulated, constitutively active, thyrocyte K+ channel required for normal thyroid hormone biosynthesis. Targeted disruption of Kcne2 in mice impaired thyroid iodide accumulation up to eightfold, impaired maternal milk ejection, halved milk tetraiodothyronine (T(4)) content and halved litter size. Kcne2-deficient mice had hypothyroidism, dwarfism, alopecia, goiter and cardiac abnormalities including hypertrophy, fibrosis, and reduced fractional shortening. The alopecia, dwarfism and cardiac abnormalities were alleviated by triiodothyronine (T(3)) and T(4) administration to pups, by supplementing dams with T(4) before and after they gave birth or by feeding the pups exclusively from Kcne2+/+ dams; conversely, these symptoms were elicited in Kcne2+/+ pups by feeding exclusively from Kcne2-/- dams. These data provide a new potential therapeutic target for thyroid disorders and raise the possibility of an endocrine component to previously identified KCNE2- and KCNQ1-linked human cardiac arrhythmias.
Keywords:Cardiac Arrhythmias, Cardiomegaly, Genetic Crosses, Heterozygote, Homozygote, Hypothyroidism, Lactation, Milk, Cardiac Myocytes, Voltage-Gated Potassium Channels, Sequence Deletion, Thyroid Gland, Thyroid Hormones, Triiodothyronine, Animals, Mice
Source:Nature Medicine
ISSN:1078-8956
Publisher:Nature Publishing Group (U.S.A.)
Volume:15
Number:10
Page Range:1186-1194
Date:October 2009
Official Publication:https://doi.org/10.1038/nm.2029
PubMed:View item in PubMed

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