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Circulating endocannabinoid concentrations during orthostatic stress

Item Type:Article
Title:Circulating endocannabinoid concentrations during orthostatic stress
Creators Name:Schroeder, C. and Batkai, S. and Engeli, S. and Tank, J. and Diedrich, A. and Luft, F.C. and Jordan, J.
Abstract:BACKGROUND: In animals, the endocannabinoid system is activated during hemodynamic insults and restrains blood pressure in part through sympathetic inhibition. MATERIALS AND METHODS: We tested the hypothesis that hemodynamic stress elicited by head-up tilt testing increases systemic endocannabinoid concentrations in humans and that excessive endocannabinoid availability predisposes to presyncope. RESULTS: With head-up tilt, 2-arachidonoylglycerol increased, whereas anandamide remained unchanged. CONCLUSIONS: In contrast to our expectations, anandamide plasma concentration at rest was directly correlated with orthostatic tolerance, rather than intolerance.
Keywords:Anandamide, 2-Arachidonoylglycerol, Endocannabinoids, Syncope, Head-Up Tilt
Source:Clinical Autonomic Research
Publisher:Springer (Germany)
Page Range:343-346
Date:December 2009
Official Publication:https://doi.org/10.1007/s10286-009-0026-1
PubMed:View item in PubMed

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