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Reciprocal requirements for EDA/EDAR/NF-{kappa}B and Wnt/{beta}-catenin signaling pathways in hair follicle induction

Official URL:https://doi.org/10.1016/j.devcel.2009.05.011
PubMed:View item in PubMed
Creators Name:Zhang, Y. and Tomann, P. and Andl, T. and Gallant, N.M. and Huelsken, J. and Jerchow, B. and Birchmeier, W. and Paus, R. and Piccolo, S. and Mikkola, M.L. and Morrisey, E.E. and Overbeek, P.A. and Scheidereit, C. and Millar, S.E. and Schmidt-Ullrich, R.
Journal Title:Developmental Cell
Journal Abbreviation:Dev Cell
Page Range:49-61
Date:21 July 2009
Keywords:DEVBIO, SIGNALING, Animals, Mice
Abstract:Wnt/{beta}-catenin and NF-{kappa}B signaling mechanisms provide central controls in development and disease, but how these pathways intersect is unclear. Using hair follicle induction as a model system, we show that patterning of dermal Wnt/{beta}-catenin signaling requires epithelial beta-catenin activity. We find that Wnt/{beta}-catenin signaling is absolutely required for NF-{kappa}B activation, and that Edar is a direct Wnt target gene. Wnt/{beta}-catenin signaling is initially activated independently of EDA/EDAR/NF-{kappa}B activity in primary hair follicle primordia. However, Eda/Edar/NF-{kappa}B signaling is required to refine the pattern of Wnt/{beta}-catenin activity, and to maintain this activity at later stages of placode development. We show that maintenance of localized expression of Wnt10b and Wnt10a requires NF-{kappa}B signaling, providing a molecular explanation for the latter observation, and identify Wnt10b as a direct NF-{kappa}B target. These data reveal a complex interplay and interdependence of Wnt/{beta}-catenin and EDA/EDAR/NF-{kappa}B signaling pathways in initiation and maintenance of primary hair follicle placodes.
Publisher:Cell Press (U.S.A.)
Additional Information:The original publication is available at www.sciencedirect.com
Item Type:Article

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