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Back to square one: what do we know about the functions of muscle LIM protein in the heart?

Item Type:Review
Title:Back to square one: what do we know about the functions of muscle LIM protein in the heart?
Creators Name:Gehmlich, K. and Geier, C. and Milting, H. and Fuerst, D. and Ehler, E.
Abstract:Muscle LIM Protein (MLP) is small, just 198 amino acid long protein, which is specifically expressed in slow skeletal muscle and cardiac tissues. This article will focus on the cardiac functions of MLP: the current knowledge about localisation data, binding partners and animal models for the protein will be summarised, and the role of MLP in maintaining a healthy heart be discussed. This review will furthermore attempt to identify gaps in our knowledge-and hence future research potential-with a special focus on MLP's role in cardiac mechano-signalling.
Keywords:Muscle LIM Protein, Hypertrophic Cardiomyopathy, Dilated Cardiomyopathy, Cardiac Hypertrophy, Mechanical Stress, Sarcomere, Animals
Source:Journal of Muscle Research and Cell Motility
ISSN:0142-4319
Publisher:Springer (Germany)
Volume:29
Number:6-8
Page Range:155-158
Date:December 2008
Official Publication:https://doi.org/10.1007/s10974-008-9159-4
PubMed:View item in PubMed

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