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Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo

Item Type:Article
Title:Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo
Creators Name:Heringer-Walther, S. and Eckert, K. and Schumacher, S.M. and Uharek, L. and Wulf-Goldenberg, A. and Gembardt, F. and Fichtner, I. and Schultheiss, H.P. and Rodgers, K. and Walther, T.
Abstract:Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34(+) and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear cells in NOD/SCID mice. Ang-(1-7) stimulated differentially human cells in bone marrow and accumulated them in the spleen. The number of HLA-I(+) and CD34(+) cells in the bone marrow was increased 42-fold and 600-fold, respectively. These results indicate a decisive impact of Ang-(1-7) on hematopoiesis and its promising therapeutic potential in diseases requiring progenitor stimulation.
Keywords:Angiotensin, CD34, Hematopoietic Stem Cell, Animals, Mice
Source:Haematologica
ISSN:0390-6078
Publisher:Ferrata Storti Foundation (Italy)
Volume:94
Number:6
Page Range:857-860
Date:June 2009
Official Publication:https://doi.org/10.3324/haematol.2008.000034
PubMed:View item in PubMed

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