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Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents

Item Type:Article
Title:Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents
Creators Name:Kleuss, C. and Hescheler, J. and Ewel, C. and Rosenthal, W. and Schultz, G. and Wittig, B.
Abstract:The inhibition of voltage-dependent Ca2+ channels in secretory cells by plasma membrane receptors is mediated by pertussis toxin-sensitive G proteins. Multiple forms of G proteins have been described, differing principally in their alpha subunits, but it has not been possible to establish which G-protein subtype mediates inhibition by a specific receptor. By intranuclear injection of antisense oligonucleotides into rat pituitary GH3 cells, the essential role of the Go-type G proteins in Ca(2+)-channel inhibition is established: the subtypes Go1 and Go2 mediate inhibition through the muscarinic and somatostatin receptors, respectively.
Keywords:Base Sequence, Calcium Channels, Carbachol, Cell Line, Cell Membrane, Antisense DNA, Electric Conductivity, Electrophysiology, GTP-Binding Proteins, Microinjections, Molecular Sequence Data, Pertussis Toxin, Pituitary Gland, Messenger RNA, Muscarinic Receptors, Neurotransmitter Receptors, Somatostatin Receptors, Signal Transduction, Somatostatin, Bordetella Virulence Factors, Animals, Rats
Source:Nature
ISSN:0028-0836
Publisher:Nature Publishing Group (U.K.)
Volume:353
Number:6339
Page Range:43-48
Date:5 September 1991
Official Publication:https://doi.org/10.1038/353043a0
PubMed:View item in PubMed

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