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Role and identification of protein kinase A anchoring proteins in vasopressin-mediated aquaporin-2 translocation

Item Type:Article
Title:Role and identification of protein kinase A anchoring proteins in vasopressin-mediated aquaporin-2 translocation
Creators Name:Klussmann, E. and Rosenthal, W.
Abstract:The antidiuretic hormone arginine vasopressin (AVP) regulates water reabsorption in renal principal cells by inducing a cAMP/protein kinase A-dependent translocation of water channels [aquaporin-2 (AQP2)] from intracellular vesicles into the apical cell membranes. Using primary cultured rat inner medullary collecting duct (IMCD) cells, it has been shown that AQP2 translocation in response to AVP stimulation occurs only if protein kinase A (PKA) is anchored to PKA anchoring proteins (AKAPs), which are present in various subcellular compartments. The identity of the AKAPs involved has not yet been elucidated. One potential candidate is a new splice variant of AKAP18, namely AKAP18 delta.
Keywords:AKAP18, Water Reabsorption, Renal Channels, CAMP/PKA, Translocation, Cell Signaling, Phosphorylation, Animals
Source:Kidney International
ISSN:0085-2538
Publisher:Nature Publishing Group (U.S.A.)
Volume:60
Number:2
Page Range:446-449
Date:August 2001
Official Publication:https://doi.org/10.1046/j.1523-1755.2001.060002446.x
PubMed:View item in PubMed

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