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Peptides for disruption of PKA anchoring

Item Type:Article
Title:Peptides for disruption of PKA anchoring
Creators Name:Hundsrucker, C. and Rosenthal, W. and Klussmann, E.
Abstract:Adaptor or scaffolding proteins are at the basis of multiprotein complexes that spatially and temporally co-ordinate the propagation and integration of a broad range of cellular events. One class of scaffolding proteins are AKAPs (A-kinase-anchoring proteins). They sequester PKA (protein kinase A) and other signalling molecules including phosphodiesterases, other protein kinases and protein phosphatases to specific subcellular compartments. AKAP-dependent protein-protein interactions play a role in many physiologically relevant processes. For example, AKAP-PKA interactions are essential for the vasopressin-mediated water re-absorption in renal collecting duct principal cells or beta-adrenoceptor-induced increases in cardiac myocyte contractility. Here, we discuss recently developed peptide disruptors of AKAP-PKA interactions. Such peptides are valuable tools to study the relevance of PKA anchoring in cellular processes.
Keywords:A-kinase-anchoring protein (AKAP), Aquaporin-2 (AQP2), CAMP, Exocytosis, Protein kinase A (PKA), Scaffolding protein
Source:Biochemical Society Transactions
Publisher:Portland Press
Number:Pt 4
Page Range:472-473
Date:1 August 2006
Official Publication:https://doi.org/10.1042/BST0340472
PubMed:View item in PubMed

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