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Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells

Item Type:Review
Title:Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells
Creators Name:Szaszak, M. and Christian, F. and Rosenthal, W. and Klussmann, E.
Abstract:Cyclic adenosine monophosphate (cAMP) is a central second messenger controlling a plethora of vital functions. Studies of cAMP dynamics in living cells have revealed markedly inhomogeneous concentrations of the second messenger in different compartments. Moreover, cAMP effectors such as cAMP-dependent protein kinase (PKA) and cAMP-activated GTP-exchange factors (Epacs) are tethered to specific cellular sites. Both the tailoring of cAMP concentrations, and the activities of cAMP-dependent signalling systems at specific cellular locations are prerequisites for most, if not all, cAMP-dependent processes. This review focuses on the role of compartmentalized cAMP signalling in exocytic processes in non-neuronal cells. Particularly, the insertion of aquaporin-2 into the plasma membrane of renal principal cells as an example for a cAMP-dependent exocytic process in a non-secretory cell type, renin secretion from juxtaglomerular cells as a cAMP-triggered exocytosis from an endocrine cell, insulin release from pancreatic beta-cells as a Ca2+-mediated and cAMP-potentiated exocytic processes in an endocrine cell, and cAMP- or Ca2+ -triggered H+ secretion from gastric parietal cells as an exocytic process in an exocrine cell are discussed. The selected examples of cAMP-regulated exocytic pathways are reviewed with regard to key proteins involved: adenylyl cyclases, phosphodiesterases, PKA, A kinase anchoring proteins (AKAPs) and Epacs.
Keywords:Adenylyl cyclase, AKAP, AQP2, Compartmentalization, Cyclic AMP, Epac, Exocytosis, H+/K+-ATPase, Insulin, PDE, PKA, Renin, Secretion, Animals
Source:Cellular Signalling
ISSN:0898-6568
Publisher:Elsevier (The Netherlands)
Volume:20
Number:4
Page Range:590-601
Date:April 2008
Official Publication:https://doi.org/10.1016/j.cellsig.2007.10.020
PubMed:View item in PubMed

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