Reactivation of hepatitis E infection in a patient with acute lymphoblastic leukaemia after allogeneic stem cell transplantation

Item Type:	Article
Title:	Reactivation of hepatitis E infection in a patient with acute lymphoblastic leukaemia after allogeneic stem cell transplantation
Creators Name:	le Coutre, P. and Meisel, H. and Hofmann, J. and Roecken, C. and Vuong, G.L. and Neuburger, S. and Hemmati, P.G. and Doerken, B. and Arnold, R.
Abstract:	Hepatitis E virus (HEV) is the major cause of several outbreaks of waterborne hepatitis in tropical and subtropical countries and of sporadic cases of viral hepatitis in endemic and industrialised countries. Generally, HEV causes an acute self-limiting hepatitis. The clinical course is characterised by transient viraemia and transaminasaemia followed by a full hepatic recovery. Recent studies describe prolonged and chronic HEV infections in some immunosuppressed patients after solid organ transplantation. Here, an indigenous acute limited hepatitis E in a patient with Philadelphia chromosome-positive acute lymphoblastic leukaemia prior to allogeneic stem cell transplantation is reported. Fourteen weeks after stem cell transplantation, reappearance of HEV viraemia was observed, with increasing viral load and modestly elevated serum transaminases. Sequence analysis of the viral RNAs revealed a reactivation of endogenous HEV genotype 3, indicating viral persistence after recovery from acute hepatitis E.
Keywords:	Viral DNA, Hepatitis E, Immunocompromised Host, Meat Products, Philadelphia Chromosome, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Viral RNA, Recurrence, Stem Cell Transplantation, Animals, Swine
Source:	Gut
ISSN:	0017-5749
Publisher:	BMJ Publishing Group
Volume:	58
Number:	5
Page Range:	699-702
Date:	May 2009
Official Publication:	https://doi.org/10.1136/gut.2008.165571
PubMed:	View item in PubMed

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