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A common variant on chromosome 11q13 is associated with atopic dermatitis

Item Type:Article
Title:A common variant on chromosome 11q13 is associated with atopic dermatitis
Creators Name:Esparza-Gordillo, J. and Weidinger, S. and Foelster-Holst, R. and Bauerfeind, A. and Rueschendorf, F. and Patone, G. and Rohde, K. and Marenholz, I. and Schulz, F. and Kerscher, T. and Huebner, N. and Wahn, U. and Schreiber, S. and Franke, A. and Vogler, R. and Heath, S. and Baurecht, H. and Novak, N. and Rodriguez, E. and Illig, T. and Lee-Kirsch, M.A. and Ciechanowicz, A. and Kurek, M. and Piskackova, T. and Macek, M. and Lee, Y.A. and Ruether, A.
Abstract:We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A of rs7927894 on chromosome 11q13.5, located 38 kb downstream of C11orf30 (P(combined) = 7.6 x 10(-10)). Approximately 13% of individuals of European origin are homozygous for rs7927894[A], and their risk of developing atopic dermatitis is 1.47 times that of noncarriers.
Keywords:Case-Control Studies, Human Pair 11 Chromosomes, Atopic Dermatitis, Genetic Predisposition to Disease, Genetic Variation, Human Genome, Linkage Disequilibrium, Single Nucleotide Polymorphism
Source:Nature Genetics
ISSN:1061-4036
Publisher:Nature Publishing Group (U.S.A.)
Volume:41
Number:5
Page Range:596-601
Date:May 2009
Official Publication:https://doi.org/10.1038/ng.347
PubMed:View item in PubMed

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