Article

Bone marrow breakout lesions act as key sites for tumor-immune cell diversification in multiple myeloma.
Lutz, R. ORCID: https://orcid.org/0009-0004-6214-308X, Poos, A.M. ORCID: https://orcid.org/0009-0009-4325-3933, Solé-Boldo, L. ORCID: https://orcid.org/0000-0002-6974-9066, John, L. ORCID: https://orcid.org/0000-0001-8178-6890, Wagner, J. ORCID: https://orcid.org/0000-0002-5087-3657, Prokoph, N. ORCID: https://orcid.org/0000-0002-6429-9895, Baertsch, M.A. ORCID: https://orcid.org/0000-0002-4000-6904, Vonficht, D., Palit, S., Brobeil, A., Mechtersheimer, G. ORCID: https://orcid.org/0000-0002-9442-3930, Hildenbrand, N. ORCID: https://orcid.org/0000-0002-3988-2018, Hemmer, S. ORCID: https://orcid.org/0009-0000-8696-2099, Steiger, S. ORCID: https://orcid.org/0000-0002-4845-5042, Horn, S., Pepke, W. ORCID: https://orcid.org/0000-0001-9690-4511, Spranz, D.M., Rehnitz, C., Sant, P. ORCID: https://orcid.org/0000-0001-9301-3211, Mallm, J.P. ORCID: https://orcid.org/0000-0002-7059-4030, Friedrich, M.J. ORCID: https://orcid.org/0000-0002-6401-3623, Reichert, P., Huhn, S., Trumpp, A. ORCID: https://orcid.org/0000-0002-6212-3466, Rippe, K. ORCID: https://orcid.org/0000-0001-9951-9395, Haghverdi, L. ORCID: https://orcid.org/0000-0001-9280-9170, Fröhling, S. ORCID: https://orcid.org/0000-0001-7907-4595, Müller-Tidow, C. ORCID: https://orcid.org/0000-0002-7166-5232, Hübschmann, D. ORCID: https://orcid.org/0000-0002-6041-7049, Goldschmidt, H. ORCID: https://orcid.org/0000-0003-0961-0035, Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Sauer, S., Raab, M.S., Haas, S. ORCID: https://orcid.org/0000-0001-9227-2051 and Weinhold, N. ORCID: https://orcid.org/0000-0002-5464-3234
Science Immunology 10 (104): eadp6667. February 2025

Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation.
Tiniakou, I. ORCID: https://orcid.org/0000-0002-8429-7045, Hsu, P.F. ORCID: https://orcid.org/0000-0001-9749-7591, Lopez-Zepeda, L.S. ORCID: https://orcid.org/0000-0001-9764-0984, Garipler, G., Esteva, E. ORCID: https://orcid.org/0000-0002-7223-6632, Adams, N.M. ORCID: https://orcid.org/0000-0001-5751-0480, Jang, G. ORCID: https://orcid.org/0000-0002-9824-1480, Soni, C. ORCID: https://orcid.org/0000-0001-7800-2338, Lau, C.M. ORCID: https://orcid.org/0000-0001-7538-094X, Liu, F., Khodadadi-Jamayran, A. ORCID: https://orcid.org/0000-0003-2495-7504, Rodrick, T.C., Jones, D., Tsirigos, A. ORCID: https://orcid.org/0000-0002-7512-8477, Ohler, U. ORCID: https://orcid.org/0000-0002-0881-3116, Bedford, M.T. ORCID: https://orcid.org/0000-0002-8899-1050, Nimer, S.D. ORCID: https://orcid.org/0000-0003-2439-7586, Kaartinen, V. ORCID: https://orcid.org/0000-0002-9432-510X, Mazzoni, E.O. ORCID: https://orcid.org/0000-0001-8994-681X and Reizis, B. ORCID: https://orcid.org/0000-0003-1140-7853
Science Immunology 9 (94): eadi1023. 12 April 2024

Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.
Li, X. ORCID: https://orcid.org/0000-0002-1173-1066, Wirtz, T. ORCID: https://orcid.org/0009-0005-5677-9804, Weber, T. ORCID: https://orcid.org/0000-0003-2079-842X, Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, Lowenstein, E.D. ORCID: https://orcid.org/0000-0003-3755-0818, Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Zach, A., Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852, de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157, Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Müller, I. ORCID: https://orcid.org/0000-0002-7477-6632, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Science Immunology 9 (92): eadi0042. 2 February 2024

A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.
Fornes, O., Jia, A., Kuehn, H.S., Min, Q., Pannicke, U., Schleussner, N. ORCID: https://orcid.org/0009-0001-3549-5600, Thouenon, R., Yu, Z., de Los Angeles Astbury, M., Biggs, C.M., Galicchio, M., Garcia-Campos, J.A., Gismondi, S., Gonzalez Villarreal, G., Hildebrand, K.J., Hönig, M., Hou, J., Moshous, D., Pittaluga, S., Qian, X., Rozmus, J., Schulz, A.S., Staines-Boone, A.T., Sun, B., Sun, J., Uwe, S., Venegas-Montoya, E., Wang, W., Wang, X., Ying, W., Zhai, X., Zhou, Q., Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117, André, I., Barth, T.F.E., Baumann, B., Brüstle, A., Burgio, G., Bustamante, J.C., Casanova, J.L., Casarotto, M.G., Cavazzana, M., Chentout, L., Cockburn, I.A., Costanza, M. ORCID: https://orcid.org/0000-0002-8959-1083, Cui, C., Daumke, O. ORCID: https://orcid.org/0000-0002-6190-1414, Del Bel, K.L., Eibel, H., Feng, X., Franke, V. ORCID: https://orcid.org/0000-0003-3606-6792, Gebhardt, J.C.M., Götz, A., Grunwald, S. ORCID: https://orcid.org/0000-0003-3978-6277, Hoareau, B., Hughes, T.R., Jacobsen, E.M., Janz, M. ORCID: https://orcid.org/0000-0002-1127-0044, Jolma, A., Lagresle-Peyrou, C., Lai, N., Li, Y., Lin, S., Lu, H.Y., Lugo-Reyes, S.O., Meng, X., Möller, P., Moreno-Corona, N., Niemela, J.E., Novakovsky, G., Perez-Caraballo, J.J., Picard, C., Poggi, L., Puig-Lombardi, M.E., Randall, K.L., Reisser, A., Schmitt, Y., Seneviratne, S., Sharma, M., Stoddard, J., Sundararaj, S., Sutton, H., Tran, L.Q., Wang, Y., Wasserman, W.W., Wen, Z., Winkler, W. ORCID: https://orcid.org/0000-0001-8807-9259, Xiong, E., Yang, A.W.H., Yu, M., Zhang, L., Zhang, H., Zhao, Q., Zhen, X., Enders, A., Kracker, S., Martinez-Barricarte, R., Mathas, S. ORCID: https://orcid.org/0000-0001-9626-1413, Rosenzweig, S.D., Schwarz, K., Turvey, S.E. and Wang, J.Y.
Science Immunology 8 (79): eade7953. January 2023

C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D. ORCID: https://orcid.org/0000-0001-8575-7560, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Weiner, J.M. ORCID: https://orcid.org/0000-0003-1438-7819, Zimmermann, K., Anania, C. ORCID: https://orcid.org/0000-0003-1549-4157, Wagner, L.K., Lyras, E.M. ORCID: https://orcid.org/0000-0003-3269-0854, Sapozhnikova, V., Lara-Astiaso, D. ORCID: https://orcid.org/0000-0001-8686-4675, Prósper, F. ORCID: https://orcid.org/0000-0001-6115-8790, Lang, R., Lupiáñez, D.G. ORCID: https://orcid.org/0000-0002-3165-036X, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Höpken, U.E. ORCID: https://orcid.org/0000-0002-0776-4893, Leutz, A. ORCID: https://orcid.org/0000-0001-8259-927X and Mildner, A. ORCID: https://orcid.org/0000-0002-2019-8427
Science Immunology 7 (75): eabj0140. September 2022

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8(+) T cell responses.
Agerer, B., Koblischke, M., Gudipati, V., Montaño-Gutierrez, L.F., Smyth, M., Popa, A., Genger, J.W., Endler, L., Florian, D.M., Mühlgrabner, V., Graninger, M., Aberle, S.W., Husa, A.M., Shaw, L.E., Lercher, A., Gattinger, P., Torralba-Gombau, R., Trapin, D., Penz, T., Barreca, D., Fae, I., Wenda, S., Traugott, M., Walder, G., Pickl, W.F., Thiel, V., Allerberger, F., Stockinger, H., Puchhammer-Stöckl, E., Weninger, W., Fischer, G., Hoepler, W., Pawelka, E., Zoufaly, A., Valenta, R., Bock, C., Paster, W., Geyeregger, R., Farlik, M., Halbritter, F., Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198, Aberle, J.H. and Bergthaler, A.
Science Immunology 6 (57): eabg6461. March 2021

The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity.
Salzer, E., Zoghi, S., Kiss, M.G., Kage, F., Rashkova, C., Stahnke, S., Haimel, M., Platzer, R., Caldera, M., Ardy, R.C., Hoeger, B., Block, J., Medgyesi, D., Sin, C., Shahkarami, S., Kain, R., Ziaee, V., Hammerl, P., Bock, C., Menche, J., Dupré, L., Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198, Sixt, M., Lomakin, A., Rottner, K., Binder, C.J., Stradal, T.E.B., Rezaei, N. and Boztug, K.
Science Immunology 5 (49): eabc3979. 10 July 2020

Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles.
Petrova, V.N., Sawatsky, B., Han, A.X., Laksono, B.M., Walz, L., Parker, E., Pieper, K. ORCID: https://orcid.org/0000-0003-4809-3157, Anderson, C.A., de Vries, R.D., Lanzavecchia, A., Kellam, P., von Messling, V., de Swart, R.L. and Russell, C.A.
Science Immunology 4 (41): eaay6125. 1 November 2019

Editorial

Good things come in threes.
Yona, S. ORCID: https://orcid.org/0000-0002-3984-2008 and Mildner, A. ORCID: https://orcid.org/0000-0002-2019-8427
Science Immunology 3 (30): eaav5545. 7 December 2018