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MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
Abualrous, E.T. and Stolzenberg, S. and Sticht, J. and Wieczorek, M. and Roske, Y. and Günther, M. and Dähn, S. and Boesen, B.B. and Calvo, M.M. and Biese, C. and Kuppler, F. and Medina-García, Á. and Álvaro-Benito, M. and Höfer, T. and Noé, F. and Freund, C.
Nature Chemical Biology 19 (10): 1196-1204. October 2023

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.
Lo, W.T. and Belabed, H. and Kücükdisli, M. and Metag, J. and Roske, Y. and Prokofeva, P. and Ohashi, Y. and Horatscheck, A. and Cirillo, D. and Krauss, M. and Schmied, C. and Neuenschwander, M. and von Kries, J.P. and Médard, G. and Kuster, Be. and Perisic, O. and Williams, R.L. and Daumke, O. and Payrastre, B. and Severin, S. and Nazaré, M. and Haucke, V.
Nature Chemical Biology 19 (1): 18-27. January 2023

Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors.
Möller, J. and Isbilir, A. and Sungkaworn, T. and Osberg, B. and Karathanasis, C. and Sunkara, V. and Grushevskyi, E.O. and Bock, A. and Annibale, P. and Heilemann, M. and Schütte, C. and Lohse, M.J.
Nature Chemical Biology 16 (9): 946-954. September 2020

Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.
Borcherds, W. and Theillet, F.X. and Katzer, A. and Finzel, A. and Mishall, K.M. and Powell, A.T. and Wu, H. and Manieri, W. and Dieterich, C. and Selenko, P. and Loewer, A. and Daughdrill, G.W.
Nature Chemical Biology 10 (12): 1000-1002. December 2014

Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism.
Degiacomi, M.T. and Iacovache, I. and Pernot, L. and Chami, M. and Kudryashev, M. and Stahlberg, H. and van der Goot, F.G. and Dal Peraro, M.
Nature Chemical Biology 9 (10): 623-629. October 2013

Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils.
Bieschke, J. and Herbst, M. and Wiglenda, T. and Friedrich, R.P. and Boeddrich, A. and Schiele, F. and Kleckers, D. and Lopez Del Amo, J.M. and Gruening, B.A. and Wang, Q. and Schmidt, M.R. and Lurz, R. and Anwyl, R. and Schnoegl, S. and Faendrich, M. and Frank, R.F. and Reif, B. and Guenther, S. and Walsh, D.M. and Wanker, E.E.
Nature Chemical Biology 8 (1): 93-101. January 2012

Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.
Bao, G. and Clifton, M. and Hoette, T.M. and Mori, K. and Deng, S.X. and Qiu, A. and Viltard, M. and Williams, D. and Paragas, N. and Leete, T. and Kulkarni, R. and Li, X. and Lee, B. and Kalandadze, A. and Ratner, A.J. and Pizarro, J.C. and Schmidt-Ott, K.M. and Landry, D.W. and Raymond, K.N. and Strong, R.K. and Barasch, J.
Nature Chemical Biology 6 (8): 602-609. August 2010

Small-molecule inhibition of APT1 affects Ras localization and signaling.
Dekker, F.J. and Rocks, O. and Vartak, N. and Menninger, S. and Hedberg, C. and Balamurugan, R. and Wetzel, S. and Renner, S. and Gerauer, M. and Schoelermann, B. and Rusch, M. and Kramer, J.W. and Rauh, D. and Coates, G.W. and Brunsveld, L. and Bastiaens, P.I. and Waldmann, H.
Nature Chemical Biology 6 (6): 449-456. June 2010