Browse by Research Team

2023

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.
Lo, W.T. and Belabed, H. and Kücükdisli, M. and Metag, J. and Roske, Y. and Prokofeva, P. and Ohashi, Y. and Horatscheck, A. and Cirillo, D. and Krauss, M. and Schmied, C. and Neuenschwander, M. and von Kries, J.P. and Médard, G. and Kuster, Be. and Perisic, O. and Williams, R.L. and Daumke, O. and Payrastre, B. and Severin, S. and Nazaré, M. and Haucke, V.
Nature Chemical Biology 19 (1): 18-27. January 2023

2022

TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation.
Tufan, A.B. and Lazarow, K. and Kolesnichenko, M. and Sporbert, A. and von Kries, J.P. and Scheidereit, C.
EMBO Journal 41 (21): e110372. 2 November 2022

Compound interaction screen on a photoactivatable cellulose membrane (CISCM) identifies drug targets.
Melder, F.T. and Lindemann, P. and Welle, A. and Trouillet, V. and Heißler, S. and Nazaré, M. and Selbach, M.
ChemMedChem 17 (19): e202200346. 6 October 2022

Rational design of highly potent, selective, and bioavailable SGK1 protein kinase inhibitors for the treatment of osteoarthritis.
Halland, N. and Schmidt, F. and Weiss, T. and Li, Z. and Czech, J. and Saas, J. and Ding-Pfennigdorff, D. and Dreyer, M.K. and Strübing, C. and Nazare, M.
Journal of Medicinal Chemistry 65 (2): 1567-1584. 27 January 2022

Aurora kinase A is involved in controlling the localization of aquaporin-2 in renal principal cells.
Baltzer, S. and Bulatov, T. and Schmied, C. and Krämer, A. and Berger, B.T. and Oder, A. and Walker-Gray, R. and Kuschke, C. and Zühlke, K. and Eichhorst, J. and Lehmann, M. and Knapp, S. and Weston, J. and von Kries, J.P. and Süssmuth, R.D. and Klussmann, E.
International Journal of Molecular Sciences 23 (2): 763. 11 January 2022

2021

Development of a 1,2,4-triazole-based lead tankyrase inhibitor: part II.
Leenders, R.G.G. and Brinch, S.A. and Sowa, S.T. and Amundsen-Isaksen, E. and Galera-Prat, A. and Murthy, S. and Aertssen, S. and Smits, J.N. and Nieczypor, P. and Damen, E. and Wegert, A. and Nazaré, M. and Lehtiö, L. and Waaler, J. and Krauss, S.
Journal of Medicinal Chemistry 64 (24): 17936-17949. 23 December 2021

Pentafluorosulfanyl (SF(5)) as a superior (19)F magnetic resonance reporter group: signal detection and biological activity of teriflunomide derivatives.
Prinz, C. and Starke, L. and Ramspoth, T.F. and Kerkering, J. and Martos Riaño, V. and Paul, J. and Neuenschwander, M. and Oder, A. and Radetzki, S. and Adelhoefer, S. and Ramos Delgado, P. and Aravina, M. and Millward, J.M. and Fillmer, A. and Paul, F. and Siffrin, V. and von Kries, J.P. and Niendorf, T. and Nazaré, M. and Waiczies, S.
ACS Sensors 6 (11): 3948–3956. 26 November 2021

Enhanced properties of a benzimidazole benzylpyrazole lysine demethylase inhibitor: mechanism-of-action, binding site analysis, and activity in cellular models of prostate cancer.
Carter, D.M. and Specker, E. and Malecki, P.H. and Przygodda, J. and Dudaniec, K. and Weiss, M.S. and Heinemann, U. and Nazaré, M. and Gohlke, U.
Journal of Medicinal Chemistry 64 (19): 14266-14282. 14 October 2021

Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis.
Bonnekoh, H. and Vera, C. and Abad-Perez, A. and Radetzki, S. and Neuenschwander, M. and Specker, E. and Mahnke, N.A. and Frischbutter, S. and Latz, E. and Nazaré, M. and von Kries, J. and Maurer, M. and Scheffel, J. and Krause, K.
Clinical and Translational Allergy 11 (5): e12045. July 2021

Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010.
Brennecke, B. and Gazzi, T. and Atz, K. and Fingerle, J. and Kuner, P. and Schindler, T. and de Weck, G. and Nazaré, M. and Grether, U.
Pharmaceutical Patent Analyst 10 (3): 111-163. May 2021

DOTAM-based, targeted, activatable fluorescent probes for the highly sensitive and selective detection of cancer cells.
Brennecke, B. and Wang, Q. and Haap, W. and Grether, U. and Hu, H.Y. and Nazaré, M.
Bioconjugate Chemistry 32 (4): 702-712. 21 April 2021

A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial differentiation.
Ostrop, J. and Zwiggelaar, R.T. and Terndrup Pedersen, M. and Gerbe, F. and Bösl, K. and Lindholm, H.T. and Díez-Sánchez, A. and Parmar, N. and Radetzki, S. and von Kries, J.P. and Jay, P. and Jensen, K.B. and Arrowsmith, C. and Oudhoff, M.J.
Frontiers in Cell and Developmental Biology 8 : 618552. 21 January 2021

Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4.
Kircher, T. and Pantsar, T. and Oder, A. and von Kries, J.P. and Juchum, M. and Pfaffenrot, B. and Kloevekorn, P. and Albrecht, W. and Selig, R. and Laufer, S.
European Journal of Medicinal Chemistry 2019 : 112901. 1 January 2021

Natural compounds and synthetic drugs to target type-2 cannabinoid (CB(2)) receptor.
Guba, W. and Nazaré, M. and Grether, U.
In: New tools to interrogate endocannabinoid signalling : from natural compounds to synthetic drugs. RSC Drug Discovery Series, 76 . Royal Society of Chemistry, Croydon, 89-167. ISBN 978-1-78801-801-2 2021

2020

From pyrazolones to azaindoles: evolution of active-site SHP2 inhibitors based on scaffold hopping and bioisosteric replacement.
Mostinski, Y. and Heynen, G.J.J.E. and López-Alberca, M.P. and Paul, J. and Miksche, S. and Radetzki, S. and Schaller, D. and Shanina, E. and Seyffarth, C. and Kolomeets, Y. and Ziebart, N. and de Schryver, J. and Oestreich, S. and Neuenschwander, M. and Roske, Y. and Heinemann, U. and Rademacher, C. and Volkamer, A. and von Kries, J.P. and Birchmeier, W. and Nazaré, M.
Journal of Medicinal Chemistry 63 (23): 14780-14804. 10 December 2020

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone, M. and Müller, M. and Chiha, S. and Ren, J. and Albat, D. and Soicke, A. and Dohmen, S. and Klein, M. and Bruns, J. and van Dinther, M. and Opitz, R. and Lindemann, P. and Beerbaum, M. and Motzny, K. and Roske, Y. and Schmieder, P. and Volkmer, R. and Nazaré, M. and Heinemann, U. and Oschkinat, H. and Ten Dijke, P. and Schmalz, H.G. and Kühne, R.
Proceedings of the National Academy of Sciences of the United States of America 117 (47): 29684-29690. 24 November 2020

Diverse chemotypes drive biased signaling by cannabinoid receptors.
Miljuš, T. and Heydenreich, F.M. and Gazzi, T. and Kimbara, A. and Rogers-Evans, M. and Nettekoven, M. and Zirwes, E. and Osterwald, A. and Rufer, A.C. and Ullmer, C. and Guba, W. and Le Gouill, C. and Fingerle, J. and Nazaré, M. and Grether, U. and Bouvier, M. and Veprintsev, D.B.
bioRxiv : 2020.11.09.375162. 10 November 2020

NMR quality control of fragment libraries for screening.
Sreeramulu, S. and Richter, C. and Kuehn, T. and Azzaoui, K. and Blommers, M.J.J. and Del Conte, R. and Fragai, M. and Trieloff, N. and Schmieder, P. and Nazaré, M. and Specker, E. and Ivanov, V. and Oschkinat, H. and Banci, L. and Schwalbe, H.
Journal of Biomolecular NMR 74 (10-11): 555-563. November 2020

Development of high-specificity fluorescent probes to enable cannabinoid type 2 receptor studies in living cells.
Sarott, R.C. and Westphal, M. and Pfaff, P. and Korn, C. and Sykes, D.A. and Gazzi, T. and Brennecke, B. and Atz, K. and Weise, M. and Mostinski, Y. and Hompluem, P. and Koers, E. and Miljus, T. and Roth, N.J. and Asmelash, H. and Vong, M.C. and Piovesan, J. and Guba, W. and Rufer, A. and Kusznir, E.A. and Huber, S. and Raposo, C. and Zirwes, E.A. and Osterwald, A. and Pavlovic, A. and Moes, S. and Beck, J. and Benito-Cuesta, I. and Grande, T. and Ruiz de Martin, S. and Yeliseev, A.A. and Drawnel, F. and Widmer, G. and Holzer, D. and van der Wel, T. and Mandhair, H. and Yuan, C.Y. and Drobyski, W. and Saroz, Y. and Grimsey, N.L. and Honer, M. and Fingerle, J. and Gawrisch, K. and Romero, J. and Hillard, C. and Varga, Z. and van der Stelt, M. and Pacher, P. and Gertsch, J. and McCormick, P. and Ullmer, C. and Oddi, S. and Maccarrone, M. and Veprintsev, D. and Nazaré, M. and Grether, U. and Carreira, E.M.
Journal of the American Chemical Society 142 (40): 16953-16964. 7 October 2020

A palladium-catalyzed domino reaction to access 3-amino-2H-indazoles from hydrazines and 2-halobenzonitriles.
Alsalim, R. and Lindemann, P. and López-Alberca, M.P. and Miksche, S. and Czechtizky, W. and Halland, N. and Nazaré, M.
Organic Letters 22 (18): 7393-7396. 18 September 2020

A semi-automated intestinal organoid screening method demonstrates epigenetic control of epithelial maturation.
Ostrop, J. and Zwiggelaar, R. and Pedersen, M.T. and Gerbe, F. and Bösl, K. and Lindholm, H.T. and Díez-Sánchez, Al. and Parmar, N. and Radetzki, S. and von Kries, J.P. and Jay, P. and Jensen, K.B. and Arrowsmith, C. and Oudhoff, M.J.
bioRxiv : 2020.07.23.217414. 24 July 2020

Preclinical lead optimization of a 1,2,4-triazole based tankyrase inhibitor.
Waaler, J. and Leenders, R. and Sowa, S.T. and Alam Brinch, S. and Lycke, M. and Nieczypor, P. and Aertssen, S. and Murthy, S. and Galera-Prat, A. and Damen, E. and Wegert, A. and Nazare, M. and Lehtiö, L. and Krauss, S.
Journal of Medicinal Chemistry 63 (13): 6834-6846. 9 July 2020

Revealing cytotoxic substructures in molecules using deep learning.
Webel, H.E. and Kimber, T.B. and Radetzki, S. and Neuenschwander, M. and Nazaré, M. and Volkamer, A.
Journal of Computer-Aided Molecular Design 34 (7): 731-746. July 2020

Dual-mode detection of bacterial 16S ribosomal RNA in tissues.
Xu, S. and Zhang, Q. and Han, X. and Wang, Y. and Wang, X. and Nazaré, M. and Jiang, J.D. and Hu, H.Y.
ACS Sensors 5 (6): 1650-1656. 26 June 2020

Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells.
Yusenko, M.V. and Trentmann, A. and Andersson, M.K. and Ghani, L.A. and Jakobs, A. and Arteaga Paz, M.F. and Mikesch, J.H. and von Kries, J.P. and Stenman, G. and Klempnauer, K.H.
Cancer Letters 479 : 61-70. 1 June 2020

An activatable lanthanide luminescent probe for time-gated detection of nitroreductase in live bacteria.
Brennecke, B. and Wang, Q. and Zhang, Q. and Hu, H.Y. and Nazaré, M.
Angewandte Chemie International Edition 59 (22): 8512-8516. 25 May 2020

Cyclin-dependent kinase 18 controls trafficking of aquaporin-2 and its abundance through ubiquitin ligase STUB1, which functions as an AKAP.
Dema, A. and Faust, D. and Lazarow, K. and Wippich, M. and Neuenschwander, M. and Zühlke, K. and Geelhaar, A. and Pallien, T. and Hallscheidt, E. and Eichhorst, J. and Wiesner, B. and Cernecká, H. and Popp, O. and Mertins, P. and Dittmar, G. and von Kries, J.P. and Klussmann, E.
Cells 9 (3): 673. 10 March 2020

2019

Small-molecule lysophosphatidic acid receptor 5 (LPAR5) antagonists: versatile pharmacological tools to regulate inflammatory signaling in BV-2 microglia cells.
Plastira, I. and Joshi, L. and Bernhart, E. and Schoene, J. and Specker, E. and Nazare, M. and Sattler, W.
Frontiers in Cellular Neuroscience 13 : 531. 29 December 2019

Probing 2H-indazoles as template for SGK1, Tie2 and SRC kinase inhibitors.
Schoene, J. and Gazzi, T. and Lindemann, P. and Christmann, M. and Volkamer, A. and Nazaré, M.
ChemMedChem 14 (16): 1514-1527. 20 August 2019

Regulation of influenza a virus mRNA splicing by CLK1.
Artarini, A. and Meyer, M. and Shin, Y.J. and Huber, K. and Hilz, N. and Bracher, F. and Eros, D. and Orfi, L. and Keri, G. and Goedert, S. and Neuenschwander, M. and von Kries, J. and Domovich-Eisenberg, Y. and Dekel, N. and Szabadkai, I. and Lebendiker, M. and Horváth, Z. and Danieli, T. and Livnah, O. and Moncorgé, O. and Frise, R. and Barclay, W. and Meyer, T.F. and Karlas, A.
Antiviral Research 168 : 187-196. August 2019

Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels.
Ullrich, F. and Blin, S. and Lazarow, K. and Daubitz, T. and von Kries, J.P. and Jentsch, T.J.
eLife 8 : e49187. 18 July 2019

Vinylphosphonites for staudinger-induced chemoselective peptide cyclization and functionalization.
Kasper, M.A and Glanz, M. and Oder, A. and Schmieder, P. and von Kries, J.P. and Hackenberger, C.P.R.
Chemical Science 10 (25): 6322-6329. 7 July 2019

High-throughput screening for modulators of CFTR activity based on genetically engineered cystic fibrosis disease-specific iPSCs.
Merkert, S. and Schubert, M. and Olmer, R. and Engels, L. and Radetzki, S. and Veltman, M. and Scholte, B.J. and Zöllner, J. and Pedemonte, N. and Galietta, L.J.V. and von Kries, J.P. and Martin, U.
Stem Cell Reports 12 (6): 1389-1403. 11 June 2019

Identification of TMEM206 proteins as pore of ASOR acid-sensitive chloride channels.
Ullrich, F. and Blin, S. and Lazarow, K. and Daubitz, T. and von Kries, J.P. and Jentsch, T.J.
bioRxiv : 667600. 11 June 2019

Rapid synthesis of γ-halide/pseudohalide-substituted cyanine sensors with programmed generation of singlet oxygen.
Zhang, Q. and Xu, S. and Lai, F. and Wang, Y. and Zhang, N. and Nazare, M. and Hu, H.Y.
Organic Letters 21 (7): 2121-2125. 5 April 2019

EU-OPENSCREEN: a novel collaborative approach to facilitate chemical biology.
Brennecke, P. and Rasina, D. and Aubi, O. and Herzog, K. and Landskron, J. and Cautain, B. and Vicente, F. and Quintana, J. and Mestres, J. and Stechmann, B. and Ellinger, B. and Brea, J. and Kolanowski, J.L. and Pilarski, R. and Orzaez, M. and Pineda-Lucena, A. and Laraia, L. and Nami, F. and Zielenkiewicz, P. and Paruch, K. and Hansen, E. and von Kries, J.P. and Neuenschwander, M. and Specker, E. and Bartunek, P. and Simova, S. and Leśnikowski, Z. and Krauss, S. and Lehtiö, L. and Bilitewski, U. and Brönstrup, M. and Taskén, K. and Jirgensons, A. and Lickert, H. and Clausen, M.H. and Andersen, J.H. and Vicent, M.J. and Genilloud, O. and Martinez, A. and Nazaré, M. and Fecke, W. and Gribbon, P.
SLAS Discovery 24 (3): 398-413. 1 March 2019

A pharmacological master key mechanism that unlocks the selectivity filter gate in K(+) channels.
Schewe, M. and Sun, H. and Mert, Ü. and Mackenzie, A. and Pike, A.C.W. and Schulz, F. and Constantin, C. and Vowinkel, K.S. and Conrad, L.J. and Kiper, A.K. and Gonzalez, W. and Musinszki, M. and Tegtmeier, M. and Pryde, D.C. and Belabed, H. and Nazare, M. and de Groot, B.L. and Decher, N. and Fakler, B. and Carpenter, E.P. and Tucker, S.J. and Baukrowitz, T.
Science 363 (6429): 875-880. 22 February 2019

A new highly thyrotropin receptor-selective small molecule antagonist with potential for the treatment of Graves' orbitopathy.
Marcinkowski, P. and Hoyer, I. and Specker, E. and Furkert, J. and Rutz, C. and Neuenschwander, M. and Sobottka, S. and Sun, H. and Nazare, M. and Berchner-Pfannschmidt, U. and von Kries, J.P. and Eckstein, A. and Schülein, R. and Krause, G.
Thyroid 29 (1): 111-123. 23 January 2019

2018

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway.
Klein, W. and Rutz, C. and Eckhard, J. and Provinciael, B. and Specker, E. and Neuenschwander, M. and Kleinau, G. and Scheerer, P. and von Kries, J.P. and Nazaré, M. and Vermeire, K. and Schülein, R.
PLoS ONE 13 (12): e0208641. 13 December 2018

CellFy: a cell-based fragment screen against C-type lectins.
Schulze, J. and Baukmann, H. and Wawrzinek, R. and Fuchsberger, F. and Specker, E. and Aretz, J. and Nazaré, M. and Rademacher, C.
ACS Chemical Biology 13 (12): 3229-3235. December 2018

Allosteric inhibition of a mammalian lectin.
Aretz, J. and Anumala, U.R. and Fuchsberger, F.F. and Molavi, N. and Ziebart, N. and Zhang, H. and Nazaré, M. and Rademacher, C.
Journal of the American Chemical Society 140 (44): 14915-14925. 7 November 2018

Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations.
Otten, C. and Knox, J. and Boulday, G. and Eymery, M. and Haniszewski, M. and Neuenschwander, M. and Radetzki, S. and Vogt, I. and Hähn, K. and De Luca, C. and Cardoso, C. and Hamad, S. and Igual Gil, C. and Roy, P. and Albiges‐Rizo, C. and Faurobert, E. and von Kries, J.P. and Campillos, M. and Tournier‐Lasserve, E. and Derry, W.B. and Abdelilah-Seyfried, S.
EMBO Molecular Medicine 10 (10): e9155. 1 October 2018

In vivo imaging of MMP-13 activity using a specific polymer-FRET peptide conjugate detects early osteoarthritis and inhibitor efficacy.
Duro-Castano, A. and Lim, N.H. and Tranchant, I. and Amoura, M. and Beau, F. and Wieland, H. and Kingler, O. and Herrmann, M. and Nazaré, M. and Plettenburg, O. and Dive, V. and Vicent, M.J. and Nagase, H.
Advanced Functional Materials 28 (37): 1802738. 12 September 2018

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Ruess, D.A. and Heynen, G.J. and Ciecielski, K.J. and Ai, J. and Berninger, A. and Kabacaoglu, D. and Görgülü, K. and Dantes, Z. and Wörmann, S.M. and Diakopoulos, K.N. and Karpathaki, A.F. and Kowalska, M. and Kaya-Aksoy, E. and Song, L. and Zeeuw van der Laan, E.A. and López-Alberca, M.P. and Nazaré, M. and Reichert, M. and Saur, D. and Erkan, M.M. and Hopt, U.T. and Sainz, B. and Birchmeier, W. and Schmid, R.M. and Lesina, M. and Algül, H.
Nature Medicine 24 (7): 954-960. July 2018

A general one-pot synthesis of 2H-indazoles using an organophosphorus-silane system.
Schoene, J. and Bel Abed, H. and Schmieder, P. and Christmann, M. and Nazaré, M.
Chemistry - A European Journal 24 (36): 9090-9100. 26 June 2018

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.
Liss, M. and Radke, M.H. and Eckhard, J. and Neuenschwander, M. and Dauksaite, V. and von Kries, J.P. and Gotthardt, M.
PLoS ONE 13 (6): e0198492. 11 June 2018

Novel strategy for the preparation of 3-perfluoroalkylated-2 H-indazole derivatives.
Bel Abed, H. and Weißing, N. and Schoene, J. and Paulus, J. and Sewald, N. and Nazaré, M.
Tetrahedron Letters 59 (19): 1813-1815. 9 May 2018

A novel nitroreductase-enhanced MRI contrast agent and its potential application in bacterial imaging.
Liu, Y. and Zhang, L. and Nazare, M. and Yao, Q. and Hu, H.Y.
Acta Pharmaceutica Sinica B 8 (3): 401-408. May 2018

Loss-of-function uORF mutations in human malignancies.
Schulz, J. and Mah, N. and Neuenschwander, M. and Kischka, T. and Ratei, R. and Schlag, P.M. and Castaños-Vélez, E. and Fichtner, I. and Tunn, P.U. and Denkert, C. and Klaas, O. and Berdel, W.E. and von Kries, J.P. and Makalowski, W. and Andrade-Navarro, M.A. and Leutz, A. and Wethmar, K.
Scientific Reports 8 (1): 2395. 5 February 2018

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.
Schrade, K. and Tröger, J. and Eldahshan, A. and Zühlke, K. and Abdul Azeez, K.R. and Elkins, J.M. and Neuenschwander, M. and Oder, A. and Elkewedi, M.M.H. and Jaksch, S. and Andrae, K. and Li, J. and Fernandes, J. and Müller, P.M. and Grunwald, S. and Marino, S.F. and Vukićević, T. and Eichhorst, J. and Wiesner, B. and Weber, M. and Kapiloff, M. and Rocks, O. and Daumke, O. and Wieland, T. and Knapp, S. and von Kries, J.P. and Klussmann, E.
PLoS ONE 13 (1): e0191423. 26 January 2018

Identification and characterization of a single high-affinity fatty acid binding site in human serum albumin.
Wenskowsky, L. and Schreuder, H. and Derdau, V. and Matter, H. and Volkmar, J. and Nazaré, M. and Opatz, T. and Petry, S.
Angewandte Chemie International Edition 57 (4): 1044-1048. 22 January 2018

2017

Discovery of a novel series of tankyrase inhibitors by a hybridization approach.
Anumala, U.R. and Waaler, J. and Nkizinkiko, Y. and Ignatev, A. and Lazarow, K. and Lindemann, P. and Olsen, P.A. and Murthy, S. and Obaji, E. and Majouga, A.G. and Leonov, S. and von Kries, J.P. and Lehtiö, L. and Krauss, S. and Nazaré, M.
Journal of Medicinal Chemistry 60 (24): 10013-10025. 28 December 2017

A chemical disruptor of the ClpX chaperone complex attenuates the virulence of multidrug-resistant Staphylococcus aureus.
Fetzer, C. and Korotkov, V.S. and Thänert, R. and Lee, K.M. and Neuenschwander, M. and von Kries, J.P. and Medina, E. and Sieber, S.A.
Angewandte Chemie International Edition 56 (49): 15746-15750. 4 December 2017

Identification of a novel benzimidazole pyrazolone scaffold that inhibits KDM4 lysine demethylases and reduces proliferation of prostate cancer cells.
Carter, D.M. and Specker, E. and Przygodda, J. and Neuenschwander, M. and von Kries, J.P. and Heinemann, U. and Nazaré, M. and Gohlke, U.
SLAS Discovery 22 (7): 801-812. 1 August 2017

Small molecules targeting human N-acetylmannosamine kinase.
Hinderlich, S. and Neuenschwander, M. and Wratil, P.R. and Oder, A. and Lisurek, M. and Nguyen, L.D. and von Kries, J.P. and Hackenberger, C.P.R.
ChemBioChem 18 (13): 1279-1285. 4 July 2017

Neuronal chemosensation and osmotic stress response converge in the regulation of aqp-8 in C. elegans.
Igual Gil, C. and Jarius, M. and von Kries, J.P. and Rohlfing, A.K.
Frontiers in Physiology 8 : 380. 9 June 2017

Direct experimental evidence for halogen-aryl π interactions in solution from molecular torsion balances.
Sun, H. and Horatscheck, A. and Martos, V. and Bartetzko, M. and Uhrig, U. and Lentz, D. and Schmieder, P. and Nazaré, M.
Angewandte Chemie International Edition 56 (23): 6454-6458. 1 June 2017

Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.
Juneja, M. and Kobelt, D. and Walther, W. and Voss, C. and Smith, J. and Specker, E. and Neuenschwander, M. and Gohlke, B.O. and Dahlmann, M. and Radetzki, S. and Preissner, R. and von Kries, J.P. and Schlag, P.M. and Stein, U.
PLoS Biology 15 (6): e2000784. 1 June 2017

A straightforward approach to N-substituted-2 H-indazol-2-amines through reductive cyclization.
Schoene, J. and Bel Abed, H. and Christmann, M. and Nazare, M.
Tetrahedron Letters 58 (16): 1633-1635. 19 April 2017

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel, C. and Pifferi, S. and Picci, C. and Gök, C. and Hoffmann, D. and Bali, K.K. and Lampe, A. and Lapatsina, L. and Fleischer, R. and Smith, E.S.J. and Bégay, V. and Moroni, M. and Estebanez, L. and Kühnemund, J. and Walcher, J. and Specker, E. and Neuenschwander, M. and von Kries, J.P. and Haucke, V. and Kuner, R. and Poulet, J.F.A. and Schmoranzer, J. and Poole, K. and Lewin, G.R.
Nature Neuroscience 20 (2): 209-218. February 2017

Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin's lymphoma.
Du, J. and Neuenschwander, M. and Yu, Y. and Däbritz, J.H.M. and Neuendorff, N.R. and Schleich, K. and Bittner, A. and Milanovic, M. and Beuster, G. and Radetzki, S. and Specker, E. and Reimann, M. and Rosenbauer, F. and Mathas, S. and Lohneis, P. and Hummel, M. and Dörken, B. and von Kries, J.P. and Lee, S. and Schmitt, C.A.
Blood 129 (1): 71-81. 5 January 2017

2016

Organophosphorus-mediated N-N bond formation: facile access to 3-amino-2H-indazoles.
Bel Abed, H. and Schoene, J. and Christmann, M. and Nazare, M.
Organic & Biomolecular Chemistry 14 (36): 8520-8528. 28 September 2016