TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008

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Item Type:	Article
Title:	TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008
Creators Name:	Uckert, W. and Schumacher, T.N.
Abstract:	The genetic introduction of T cell receptor genes into T cells has been developed over the past decade as a strategy to induce defined antigen-specific T cell immunity. With the potential value of TCR gene therapy well-established in murine models and the feasibility of infusion of TCR-modified autologous T cells shown in a first phase I trial, the next key step will be to transform TCR gene transfer from an experimental technique into a robust clinical strategy. In this review, we discuss the different properties of the TCR transgene and transgene cassette that can strongly affect both the efficacy and the safety of TCR gene transfer.
Keywords:	T Lymphocytes, Adoptive T Cell Therapy, TCR Gene Transfer, TCR Engineering
Source:	Cancer Immunology Immunotherapy
ISSN:	0340-7004
Publisher:	Springer
Volume:	58
Number:	5
Page Range:	809-822
Date:	May 2009
Additional Information:	The original publication is available at www.springerlink.com
Official Publication:	https://doi.org/10.1007/s00262-008-0649-4
PubMed:	View item in PubMed

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