Tyrosine-phosphorylated bacterial effector proteins: the enemies within

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Item Type:	Review
Title:	Tyrosine-phosphorylated bacterial effector proteins: the enemies within
Creators Name:	Backert, S. and Selbach, M.
Abstract:	The tyrosine phosphorylation of proteins has a central role during signal transduction in eukaryotes. Recent progress shows that tyrosine phosphorylation is also a common feature of several effector proteins translocated by bacterial type III and type IV secretion systems. The involvement of these secretion systems in disease development is exemplified by a variety of pathogenic processes: pedestal formation (Tir of EPEC and Citrobacter), cell scattering (CagA of Helicobacter), invasion (Tarp of Chlamydia) and possibly proinflammatory responses and cell proliferation (BepD-F of Bartonella). The discovery that different bacterial pathogens use this common strategy to subvert host-cell function suggests that more examples will soon emerge.
Keywords:	Bacterial Antigens, Bacterial Physiology, Bacterial Proteins, Escherichia coli Proteins, Phosphorylation, Cell Surface Receptors, Tyrosine
Source:	Trends in Microbiology
ISSN:	0966-842X
Publisher:	Elsevier Science London
Volume:	13
Number:	10
Page Range:	476-484
Date:	October 2005
Official Publication:	https://doi.org/10.1016/j.tim.2005.08.002
PubMed:	View item in PubMed

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