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| Item Type: | Article |
|---|---|
| Title: | E-I balance and human diseases - from molecules to networking |
| Creators Name: | Eichler, S.A. and Meier, J.C. |
| Abstract: | Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development. This review contains recent information about the molecular mechanisms orchestrating the establishment and maintenance of this excitation-inhibition (E-I) balance, and it reviews examples of deregulation of inhibitory and excitatory systems at a molecular, network and disease level of investigation. |
| Keywords: | Development, Excitation-inhibition balance, Homeostasis, Hyperexcitability, Autism, Nervous system disorders, Excitation, Inhibition, E-I balance, Mental retardation, Schizophrenia, Alzheimer's disease, Rett Syndrome |
| Source: | Frontiers in Molecular Neuroscience |
| ISSN: | 1662-5099 |
| Publisher: | Frontiers Media SA |
| Volume: | 1 |
| Number: | 2 |
| Date: | 28 March 2008 |
| Official Publication: | https://doi.org/10.3389/neuro.02.002.2008 |
| PubMed: | View item in PubMed |
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