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| Item Type: | Article |
|---|---|
| Title: | Polymorphism of IL-1alpha, IL-1beta and IL-10 in patients with advanced ovarian cancer: Results of a prospective study with 147 patients |
| Creators Name: | Braicu, E.I., Mustea, A., Toliat, M.R., Pirvulescu, C., Koensgen, D., Sun, P., Nuernberg, P., Lichtenegger, W. and Sehouli, J. |
| Abstract: | OBJECTIVE.: Interleukin 1 (IL-1) and IL-10 are critically involved in tumorigenesis. We investigated polymorphisms of IL-1 and IL-10 genes in patients with ovarian cancer (OC). METHODS.: In a prospective, case-control study 147 patients with OC and 129 patients without history of any malignancy (CG) were genotyped for IL-1 gene (IL-1alpha -889 T/C and IL-1beta -511 C/T) and IL-10 gene (IL-10 -1082 G/A, -819 C/T and -592 C/A) using pyrosequencing. RESULTS.: IL-10 polymorphisms in -819 and -592 positions correlated with the postoperative residual tumor mass (p=0.036 and p=0.035, respectively). The chance of achieving optimal tumor debulking was 1.49 times greater for patients with the C/C genotype at -819 and -512 positions than for patients with other genotypes. There were no significant associations between allelic frequencies for IL-1alpha and IL-1beta in OC. IL-10 -819 CC and -592 CC genotypes were associated in univariate analysis with a better disease-free and overall survival. CONCLUSIONS.: IL-10 promoter polymorphism may be related with the ability to achieve optimal tumor debulking. Polymorphism in IL-10 gene seems to influence the overall and disease-free survival rate. Subsequent multi-institutional studies with high number of patients are warranted to confirm these results. |
| Keywords: | Ovarian cancer, Cytokines, Polymorphism, IL-1alpha, IL-1beta, IL-10 |
| Source: | Gynecologic Oncology |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier |
| Volume: | 104 |
| Page Range: | 680-685 |
| Date: | March 2007 |
| Official Publication: | https://doi.org/10.1016/j.ygyno.2006.10.014 |
| PubMed: | View item in PubMed |
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