Continuous tooth generation in mouse is induced by activated epithelial Wnt/β-catenin signaling

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Item Type:	Article
Title:	Continuous tooth generation in mouse is induced by activated epithelial Wnt/β-catenin signaling
Creators Name:	Jaervinen, E., Salazar-Ciudad, I., Birchmeier, W., Taketo, M.M., Jernvall, J. and Thesleff, I.
Abstract:	The single replacement from milk teeth to permanent teeth makes mammalian teeth different from teeth of most nonmammalian vertebrates and other epithelial organs such as hair and feathers, whose continuous replacement has been linked to Wnt signaling. Here we show that mouse tooth buds expressing stabilized beta-catenin in epithelium give rise to dozens of teeth. The molar crowns, however, are typically simplified unicusped cones. We demonstrate that the supernumerary teeth develop by a renewal process where new signaling centers, the enamel knots, bud off from the existing dental epithelium. The basic aspects of the unlocked tooth renewal can be reproduced with a computer model on tooth development by increasing the intrinsic level of activator production, supporting the role of beta-catenin pathway as an upstream activator of enamel knot formation. These results may implicate Wnt signaling in tooth renewal, a capacity that was all but lost when mammals evolved progressively more complicated tooth shapes.
Keywords:	Organ renewal, Regeneration, Tooth development, Activator-inhibitor model, Animals, Mice
Source:	Proceedings of the National Academy of Sciences of the United States of America
ISSN:	0027-8424
Publisher:	National Academy of Sciences
Volume:	103
Number:	49
Page Range:	18627-18632
Date:	5 December 2006
Official Publication:	https://doi.org/10.1073/pnas.0607289103
PubMed:	View item in PubMed

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