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Receptor-mediated gene delivery

Item Type:Article
Title:Receptor-mediated gene delivery
Creators Name:Gust, T.C. and Zenke, M.
Abstract:Receptor-mediated gene delivery capitalises on the presence of specific cell surface molecules for DNA uptake into cells and represents a particularly appealing approach for targeting vector DNA to specific cell types in vivo and in vitro. Various ligand/DNA and antibody/DNA transfer complexes were generated that, following binding to cells, are internalised and reach the endosomal compartment. Vector complexes contain endosomolytic components that ensure vector release from the endosome and translocation of vector DNA into the nucleus where transcription occurs. Thus, receptor-mediated gene delivery encompasses several critical steps that must be considered when designing and applying such vector systems.
Keywords:Animals, Biological Transport, Cell Nucleus, Cell Surface Receptors, DNA, Gene Therapy, Gene Transfer Techniques, Genetic Techniques
Page Range:224-229
Date:24 January 2002
Official Publication:https://doi.org/10.1100/tsw.2002.95
PubMed:View item in PubMed

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