ERAD: the long road to destruction

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Item Type:	Review
Title:	ERAD: the long road to destruction
Creators Name:	Meusser, B., Hirsch, C., Jarosch, E. and Sommer, T.
Abstract:	Endoplasmic reticulum (ER)-associated protein degradation (ERAD) eliminates misfolded or unassembled proteins from the ER. ERAD targets are selected by a quality control system within the ER lumen and are ultimately destroyed by the cytoplasmic ubiquitin-proteasome system (UPS). The spatial separation between substrate selection and degradation in ERAD requires substrate transport from the ER to the cytoplasm by a process termed dislocation. In this review, we will summarize advances in various aspects of ERAD and discuss new findings on how substrate dislocation is achieved.
Keywords:	Endoplasmic Reticulum, Membrane Transport Proteins, Biological Models, Proteasome Endopeptidase Complex, Protein Folding, Protein Transport, Proteins, Ubiquitin, Ubiquitin-Protein Ligase Complexes, Ubiquitin-Protein Ligases, Yeasts, Animals
Source:	Nature Cell Biology
ISSN:	1465-7392
Publisher:	Nature Publishing Group
Volume:	7
Number:	8
Page Range:	766-772
Date:	August 2005
Official Publication:	https://doi.org/10.1038/ncb0805-766
PubMed:	View item in PubMed

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