Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

A subpopulation of precursor cells in the mouse dentate gyrus receives synaptic GABAergic input

Item Type:Article
Title:A subpopulation of precursor cells in the mouse dentate gyrus receives synaptic GABAergic input
Creators Name:Wang, L.P., Kempermann, G. and Kettenmann, H.
Abstract:Fate choice decision and the initiation of neuronal development occur in precursor cells of the adult dentate gyrus. We here show that the earliest signs of neuronal function can be detected in a nestin-positive progenitor cell population, which is morphologically distinct from the putative radial glia-like stem cells. Whereas radial glia-like stem cells had a glial physiological phenotype, this other cell population was more heterogeneous including cells with the ability to generate action potentials. These cells had only plump horizontal processes or lacked processes. Some of these cells received spontaneous and evoked synaptic input, which was sensitive to GABAA, but not to glutamate receptor antagonists. In radial glia-like stem cells, such a response was not observed. However, both types of precursor cells expressed functional GABAA and glutamate receptors and glutamate transporters. This early establishment of GABAergic innervation in adult neurogenesis thus mimics the pattern described for brain development.
Keywords:Action Potentials, Amino Acid Transport System X-AG, Cell Differentiation, Dentate Gyrus, Excitatory Amino Acid Agonists, GABA Antagonists, GABA-A Receptors, Gamma-Aminobutyric Acid, Glutamate Receptors, Intermediate Filament Proteins, Nerve Tissue Proteins, Neural Pathways, Neuroglia, Neurons, Organ Culture Techniques, Stem Cells, Synapses, Transgenic Mice, Animals, Mice
Source:Molecular and Cellular Neuroscience
ISSN:1044-7431
Publisher:Academic Press
Volume:29
Number:2
Page Range:181-189
Date:1 January 2005
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library