Association of the HLA region with multiple sclerosis as confirmed by a genome screen using >10,000 SNPs on DNA chips

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Item Type:	Article
Title:	Association of the HLA region with multiple sclerosis as confirmed by a genome screen using >10,000 SNPs on DNA chips
Creators Name:	Goedde, R., Rohde, K., Becker, C., Toliat, M., Entz, P., Suk, A., Mueller, N., Sindern, E., Haupts, M., Schimrigk, S., Nuernberg, P. and Epplen, J.
Abstract:	Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, with a complex genetic background. Here, we present a genome screen for association in small scale, employing 11,555 single nucleotide polymorphisms (SNPs) on DNA chips for genotyping 100 MS patients stratified for HLA-DR2 + and 100 controls. More than 500 SNPs revealed significant differences between cases and controls before Bonferroni correction. A fraction of these SNPs was reanalysed in two additional cohorts of patients and controls, using high-throughput genotyping methods. A marker on chromosome 6p21.32 (rs2395182) yielded the highest significance level, validating the established HLA-DR association.
Keywords:	Genetic Markers, Genetic Screening, Genome, HLA-DR Antigens, HLA-DR2 Antigen, Linkage, Multiple Sclerosis, Oligonucleotide Array Sequence Analysis, Single Nucleotide Polymorphism
Source:	Journal of Molecular Medicine
ISSN:	0946-2716
Publisher:	Springer
Volume:	83
Number:	6
Page Range:	486-494
Date:	1 January 2005
Official Publication:	https://doi.org/10.1007/s00109-005-0650-8
PubMed:	View item in PubMed

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