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| Item Type: | Article |
|---|---|
| Title: | Role of T-type calcium current in identified D-hair mechanoreceptor neurons studied in vitro |
| Creators Name: | Dubreuil, A.S., Boukhaddaoui, H., Desmadryl, G., Martinez-Salgado, C., Moshourab, R., Lewin, G.R., Carroll, P., Valmier, J. and Scamps, F. |
| Abstract: | Different subsets of dorsal root ganglion (DRG) mechanoreceptors transduce low- and high-intensity mechanical stimuli. It was shown recently that, in vivo, neurotrophin-4 (NT-4)-dependent D-hair mechanoreceptors specifically express a voltage-activated T-type calcium channel (Ca(v)3.2) that may be required for their mechanoreceptive function. Here we show that D-hair mechanoreceptors can be identified in vitro by a rosette-like morphology in the presence of NT-4 and that these rosette neurons are almost all absent in DRG cultures taken from NT-4 knock-out mice. In vitro identification of the D-hair mechanoreceptor allowed us to explore the electrophysiological properties of these cells. We demonstrate that the T-type Ca(v)3.2 channel induced slow membrane depolarization that contributes to lower the voltage threshold for action potential generation and controls spike latency after stimulation of D-hair mechanoreceptors. Indeed, the properties of the T-type amplifier are particularly well suited to explain the high sensitivity of D-hair mechanoreceptors to slowly moving stimuli. |
| Keywords: | T-type Calcium Channel, Cav3.2, Neurotrophin, Mechanotransduction, D-Hair Neuron, Dorsal Root Ganglion, Animals, Mice |
| Source: | Journal of Neuroscience |
| ISSN: | 0270-6474 |
| Publisher: | Society for Neuroscience |
| Volume: | 24 |
| Number: | 39 |
| Page Range: | 8480-8484 |
| Date: | 29 September 2004 |
| Additional Information: | Copyright (c) 2004 by The Society for Neuroscience |
| Official Publication: | https://doi.org/10.1523/JNEUROSCI.1598-04.2004 |
| PubMed: | View item in PubMed |
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