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| Item Type: | Article |
|---|---|
| Title: | Non-specific removal of antibodies in patients with idiopathic dilated cardiomyopathy: implications for xenotransplantation |
| Creators Name: | Knosalla, C., Mueller, J., Moran, K., Wallukat, G., Hetzer, R. and Cooper, D.K.C. |
| Abstract: | We assessed the efficiency of non-specific extracorporeal immunoadsorption (EIA), using polyclonal anti-human immunoglobulin antibodies, in depleting the serum of anti-galactose{alpha}1,3galactose (Gal) antibody and in decreasing serum cytotoxicity in 5 patients with idiopathic dilated cardiomyopathy. The mean concentrations of anti-Gal immunoglobulin (Ig)M and IgG before EIA were 74 μg/ml and 159 μg/ml, respectively. After EIA, these concentrations decreased by 86% and 88%, respectively. Both anti-Gal IgM and IgG returned to pre-EIA concentrations within 1 month, without rebound to greater than baseline concentrations. After EIA, mean serum cytotoxicity also decreased from 90% to 17%, with recovery by 1 month. Extracorporeal immunoadsorption proved safe in patients with heart failure and was effective in depleting anti-Gal antibody and in decreasing serum cytotoxicity to pig cells. |
| Keywords: | Anti-Idiotypic Antibodies, Autoantibodies, Dilated Cardiomyopathy, Disaccharides, Heart, Heart Transplantation, Immunoglobulin G, Immunoglobulin M, Immunosorbent Techniques, Myocardium, Heterologous Transplantation, Animals, Swine |
| Source: | Journal of Heart and Lung Transplantation |
| ISSN: | 1053-2498 |
| Publisher: | Elsevier |
| Volume: | 23 |
| Number: | 5 |
| Page Range: | 623-626 |
| Date: | May 2004 |
| Official Publication: | https://doi.org/10.1016/S1053-2498(03)00229-8 |
| PubMed: | View item in PubMed |
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